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MicroRNA regulation constrains the organization of target genes on mammalian chromosomes

By Zhen-Zhen Wang, Bin-Sheng Gong, Hua-Kun Wang, Hong-Jiu Wang, Meng Zhou, Qiang-Hu Wang, Xi Chen, Tao Liu and Xia Li

Abstract

AbstractThe regulation of microRNAs (miRNAs) is a complicated process requiring a large number of molecular events to be coordinated in both space and time. It is not known whether this complicated regulation process constrains the organization of target genes on mammalian chromosomes. We performed a genome-wide analysis to provide a better picture of chromosomal organization of miRNA target genes. Our results showed clustering of the target genes (TGs) of miRNAs on mammalian chromosomes, and further revealed that the particular gene organization is constrained by miRNA regulation. The clustering pattern of TGs provides an insight into the complexity of miRNA regulation

Publisher: Federation of European Biochemical Societies. Published by Elsevier B.V.
Year: 2011
DOI identifier: 10.1016/j.febslet.2011.04.059
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