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Evaluation of Uric Acid as a Prognostic Blood-Based Marker in a Large Cohort of Pancreatic Cancer Patients

By Stotz Michael, Szkandera Joanna, Seidel Julia, Stojakovic Tatjana, Samonigg Hellmut, Reitz Daniel, Gary Thomas, Kornprat Peter, Schaberl-Moser Renate, Hoefler Gerald, Gerger Armin and Pichler Martin


Recently, chemical blood parameters gain more attraction as potential prognostic parameters in pancreatic cancer (PC). In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall survival (OS) in a large cohort of patients with PC.Data from 466 consecutive patients with ductal adenocarcinoma of the pancreas were evaluated retrospectively. Overall survival (OS) was analysed using the Kaplan-Meier method. To further evaluate the prognostic significance of the UA level, univariate and multivariate Cox regression models were calculated. = 0.011).In conclusion, we identified the UA level at time of diagnosis as an independent prognostic factor in PC patients. Our results indicate that the UA level might represent a novel and useful marker for patient stratification in PC management

Publisher: Public Library of Science
Year: 2014
DOI identifier: 10.1371/journal.pone.0104730
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