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Variant Is Associated with an Increased Risk of Bacterial Infections after Orthotopic Liver Transplantation

By Janse Marcel, de Rooij Bert-Jan F., van Hoek Bart, van den Berg Arie P., Porte Robert J., Blokzijl Hans, Coenraad Minneke J., Hepkema Bouke G., Schaapherder Alexander F., Ringers Jan, Weersma Rinse K. and Verspaget Hein W.

Abstract

, which was reported to be associated with increased risk of spontaneous bacterial peritonitis in cirrhotic patients. gene variants was determined with cumulative incidence curves and log-rank analysis. variants in the donor. R702W genotype in the recipient is independently associated with an increased risk of bacterial infections after liver transplantation, indicating a predisposing role for this genetic factor impairing the recipient’s innate immune system

Publisher: Public Library of Science
Year: 2013
DOI identifier: 10.1371/journal.pone.0072617
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