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Drug delivery systems based on nucleic acid nanostructures

By Jan Willem de Vries, Feng Zhang and Andreas Herrmann

Abstract

<p>The field of DNA nanotechnology has progressed rapidly in recent years and hence a large variety of 1D-, 2D-and 3D DNA nanostructures with various sizes, geometries and shapes is readily accessible. DNA-based nanoobjects are fabricated by straight forward design and self-assembly processes allowing the exact positioning of functional moieties and the integration of other materials. At the same time some of these nanosystems are characterized by a low toxicity profile. As a consequence, the use of these architectures in a biomedical context has been explored. In this review the progress and possibilities of pristine nucleic acid nanostructures and DNA hybrid materials for drug delivery will be discussed. For the latter class of structures, a distinction is made between carriers with an inorganic core composed of gold or silica and amphiphilic DNA block copolymers that exhibit a soft hydrophobic interior. (C) 2013 Elsevier B.V. All rights reserved.</p>

Topics: DNA, Nanoparticles; Nanotechnology; Drug delivery; Colloidal gold particles; DNA block copolymers; DNA BLOCK-COPOLYMER; MESOPOROUS SILICA NANOPARTICLES; MACROPHAGE SCAVENGER RECEPTORS; ROLLING CIRCLE AMPLIFICATION; MODIFIED GOLD NANOPARTICLES; VESICULAR STOMAT
Year: 2013
DOI identifier: 10.1016/j.jconrel.2013.05.022
OAI identifier: oai:pure.rug.nl:publications/2ba53d2d-2a68-4e0e-a47e-d7fceffadd19
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