Skip to main content
Article thumbnail
Location of Repository

Family history of alcohol dependence and gray matter abnormalities in non-alcoholic adults

By Zsuzsika Sjoerds, Marie-Jose Van Tol, Wim van den Brink, Nic J. A. Van der Wee, Mark A. Van Buchem, Andre Aleman, Brenda W. J. H. Penninx and Dick J. Veltman

Abstract

<p>Objectives. Alcohol-use disorders in adolescents are associated with gray matter (GM) abnormalities suggesting neurotoxicity by alcohol. However, recently similar GM abnormalities were found in non-drinking children with a family history (FH) of alcohol dependence (AD). The question thus rises whether these abnormalities represent a transient delay in brain maturation or a persistent risk factor for developing neuropsychiatric disorders, rather than a (neurotoxic) consequence of AD. This study investigated whether a FH of AD in non-drinking adults is associated with abnormal GM-volumes similar to those observed in drinking and non-drinking adolescents with a FH of AD. Methods. GM-images were analyzed using Voxel-Based Morphometry in non-alcoholics with (FH+; N = 36) and without (FH-; N = 107) familial AD. Additionally we controlled for possible confounders: diagnosis of depression/anxiety, childhood trauma and familial depression/ anxiety. Results. Smaller GM-volumes were shown in the right parahippocampal gyrus in FH+ compared with FH-. Results were unaffected by confounders. Conclusions. We demonstrated an effect of familial AD in non-alcoholic adults on GM volume in the parahippocampal gyrus, similar to drinking and non-drinking FH+ adolescents. These findings suggest that GM abnormalities in the parahippocampal gyrus represent a persistent biological susceptibility for AD or related psychopathology and not neurotoxicity of alcohol or delayed brain maturation.</p>

Topics: Alcohol-related disorders, family; parahippocampal gyrus; cerebral cortex; magnetic resonance imaging; VOXEL-BASED MORPHOMETRY; POSTTRAUMATIC-STRESS-DISORDER; SMALLER HIPPOCAMPAL VOLUME; SUBSTANCE-USE DISORDERS; HIGH-RISK; PSYCHOMETRIC PROPERTIES; ANXIETY DISORDERS; PANIC DISORDER;
Year: 2013
DOI identifier: 10.3109/15622975.2011.640942
OAI identifier: oai:pure.rug.nl:publications/81fadf6f-894d-42f7-9271-0c2c0053cdf6
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.3109/1562... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.