Skip to main content
Article thumbnail
Location of Repository

Role of notch signaling in osteoimmunology-from the standpoint of osteoclast differentiation

By Li Duan and Yijin Ren

Abstract

<p>The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Osteoimmunology comprises the interplay between the immune system and bone metabolism. Osteoclasts, cells that resorb bone, play a crucial role in bone metabolism. In this review, we discuss the role of Notch signaling in osteoimmunology that is crucial for physiological bone remodeling (such as in orthodontic tooth movement, where bone remodeling is in balance) and undue non-physiological Notch signaling which results in pathological bone remodeling (such as in rheumatoid arthritis and periodontitis, where bone remodeling is out of balance) from the point view of osteoclast differentiation. A proposal is made that Notch signaling not only controls immune system reaction but also interferes with osteoclast differentiation involved in the bone remodeling process. Therefore, Notch signaling could be a promising therapeutic target at conditions that cross link the immune system with the skeletal system.</p>

Topics: ZONE B-CELLS, ORTHODONTIC TOOTH MOVEMENT; CD4(+) T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ANTIGEN-PRESENTING CELLS; NF-KAPPA-B; IN-VIVO; IMMUNE-SYSTEM; DENDRITIC CELLS; RHEUMATOID-ARTHRITIS
Year: 2013
DOI identifier: 10.1093/ejo
OAI identifier: oai:pure.rug.nl:publications/737eec95-4c81-49a3-aca6-1d4ebaff8248
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.1093/ejo/... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.