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RENAL VASCULITIS IN 2012 Reclassification and the introduction of biologicals

By Cees G. M. Kallenberg

Abstract

<p>2012 saw the classification of the systemic vasculitides revised. Genetic studies showed that granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are different diseases with aberrant immune responses to different autoantigens. B-cell depletion with rituximab also acquired a primary role in the treatment of GPA and MPA, as well as in cryoglobulinaemic vasculitis. Kallenberg, C. G. M. Nat. Rev. Nephrol. 9, 70-72 (2013); published online 8 January 2013; doi:10.1038/nrneph.2012.284</p>

Topics: ANCA-ASSOCIATED VASCULITIS, ANTIBODY-ASSOCIATED VASCULITIS; DAILY ORAL CYCLOPHOSPHAMIDE; REMISSION INDUCTION; RANDOMIZED-TRIAL; RITUXIMAB; MAINTENANCE; PULSE
Year: 2013
DOI identifier: 10.1038/nrneph.2012.284
OAI identifier: oai:pure.rug.nl:publications/32452b9a-d2fb-44a1-a439-be41f6cc19dc
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