10.1371/journal.pone.0001849

Locus in Congenital Growth Disorders and Cancer

Abstract

DMR0 methylation changes in the aetiology of BWS or SRS is unknown..These results support a model in which DMR0 and IC1 have opposite susceptibilities to global hyper and hypomethylation during tumorigenesis independent of the parent of origin imprint. In contrast, during embryogenesis DMR0 is methylated or demethylated according to the germline methylation imprint at the IC1, indicating different mechanisms of imprinting loss in neoplastic and non-neoplastic cells

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This paper was published in Public Library of Science (PLOS).

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