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Mesoporous Silica and Composite Nanostructures for Theranostics

By V.A. Khanadeev, B.N. Khlebtsov, G.S. Terentyuk, D.S. Chumakov, M.V. Basko, A.B. Bucharskaya, E.A. Genina, A.N. Bashkatov and N.G. Khlebtsov

Abstract

We discus methods for fabrication of silica and composite nanoparticles, which can be used in various biomedical applications. The most promising types of such nanostructures are hollow silica nanosheres, sil-ica coated plasmon-resonant nanoparticles (gold nanorods and gold-silver nanocages) and nanorattles. Mesoporous silica shell can be doped by desirable targeting molecules. Here we present the results of for-mation of nanocomposites composed of gold nanorods and double-layer silica shell. The secondary mesopo-rous silica shell is doped with a photosensitizer (hematoporphyrine in our case). We demonstate some of promising theranostics applications of these nanocomposites for bioimaging and in vivo therapy of tumors. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3548

Topics: Mesoporous silica, Nanoparticles, Nanocomposites, Theranostics, Photodynamic therapy
Publisher: Sumy State University
Year: 2013
OAI identifier: oai:essuir.sumdu.edu.ua:123456789/35481
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