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Spatiotemporal control of cyclic AMP immunomodulation through the PKA–Csk inhibitory pathway is achieved by anchoring to an Ezrin–EBP50–PAG scaffold in effector T cells

By Isabelle Cornez and Kjetil Taskén


AbstractA variety of immunoregulatory signals to effector T cells from monocytes, macrophages and regulatory T cells act through cyclic adenosine monophosphate. In the effector T cell, the protein kinase A (PKA) type I isoenzyme localizes to lipid rafts during T cell activation and modulates directly the proximal events that take place after engagement of the T cell receptor. The most proximal target for PKA phosphorylation is C-terminal Src kinase (Csk), which initiates a negative signal pathway that fine-tunes the T cell activation process. The A kinase anchoring protein Ezrin colocalizes PKA and Csk by forming a supramolecular signaling complex consisting of PKA, Ezrin, Ezrin/radixin/moesin (ERM) binding protein of 50kDa (EBP50), phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (GEMs) (PAG) and Csk

Publisher: Federation of European Biochemical Societies. Published by Elsevier B.V.
Year: 2010
DOI identifier: 10.1016/j.febslet.2010.04.056
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