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Psychological stress is related to a decrease of serum anti-müllerian hormone level in infertile women

By Yue-zhi Dong, Fei-jing Zhou and Ying-pu Sun


Abstract Background Stress exposure has been proved to be linked to reproductive failure. The reproductive potential of women depends on the ovarian reserve. Anti-müllerian hormone (AMH) has been proved a reliable clinical marker of ovarian reserve. However, the correlation between psychological stress and AMH level is not clear. Methods A cross-sectional study including 576 women was conducted. AMH concentration was tested to reflect the ovarian reserve. Salivary alpha-amylase (SAA) level was measured to assess the stress of patients objectively. Results The SAA level was significantly, and negatively correlated with AMH levels in infertile women (r = −0.315, P = 0.000; adjusted for age, r = −0.336, P = 0.000). Conclusion Higher psychological stress was related to a decreased AMH level in infertile women and psychological stress may affect ovarian reserve

Topics: Stress, Anti-müllerian hormone, Ovarian reserve, Infertility, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Publisher: BMC
Year: 2017
DOI identifier: 10.1186/s12958-017-0271-4
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