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The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

By Kevin Boyé, Nadège Pujol, Isabel D Alves, Ya-Ping Chen, Thomas Daubon, Yi-Zong Lee, Stephane Dedieu, Marion Constantin, Lorenzo Bello, Marco Rossi, Rolf Bjerkvig, Shih-Che Sue, Andreas Bikfalvi and Clotilde Billottet

Abstract

The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration

Topics: Science, Q
Publisher: Nature Publishing Group
Year: 2017
DOI identifier: 10.1038/s41467-017-01686-y
OAI identifier: oai:doaj.org/article:f1c4e60c36fd44feb5c242fd49223739
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