Study of clinical, laboratory, and upper gastrointestinal endoscopic profile in patients of alcoholic liver disease in Sikkim


Background: Alcoholic liver disease (ALD) is the most common liver disease in India, caused by excessive intake of alcohol even though being a preventable disease. The three principal types of ALD are fatty liver, alcoholic hepatitis, and cirrhosis. Objectives: Study of clinical presentation, laboratory parameters, abdominal sonographic and upper gastrointestinal endoscopic findings, and complications in patients of ALD in Sikkim. Methods: Descriptive observational hospital-based study was carried on 100 ALD patients admitted in Department of General Medicine in a teaching hospital of Sikkim, who fulfilled the inclusion criteria. Data were tabulated and analyzed using IBM-SPSS statistics version 22 software. Results: The mean age was 48 years with majority being males (84%), occupied in unskilled work (67%), with lower education level (52%), and belonging to middle socioeconomic status (56%). The average intake of alcohol by males was 63 g/day, and in females, it was 40 g/day with average duration of alcohol intake being 16 years. Most common presenting features were nausea (90%), jaundice (67%), and anorexia (64%). The mean total bilirubin (mg/dL), aspartate aminotransferase (IU/L), alanine aminotransferase (IU/L), serum albumin (g/dL), and prothrombin time difference (seconds) were 4.74, 110.2, 59.1, 3.4, and 4.1. Abdominal sonography revealed ascites (53%) and cirrhosis (43%), and upper gastrointestinal endoscopy revealed varices (52%) as common finding. The most common complications were gastrointestinal bleeding (54%) and portal hypertension (51%). Conclusions: Due to high mortality and morbidity associated with this preventable liver disease along with a multidisciplinary approach to tackle this alcohol menace, a sound regional knowledge of clinical presentation and workup findings can help in effective treatment strategies of the same

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oai:doaj.org/article:2ab82c2ca05e42f085685cfd823b5f1dLast time updated on 6/4/2019

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