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Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

By Douglas McCloskey, Sibei Xu, Troy E. Sandberg, Elizabeth Brunk, Ying Hefner, Richard Szubin, Adam M. Feist and Bernhard O. Palsson


The function of metabolic genes in the context of regulatory networks is not well understood. Here, the authors investigate the adaptive responses of E. coli after knockout of metabolic genes and highlight the influence of metabolite levels in the evolution of regulatory function

Topics: Science, Q
Publisher: Nature Publishing Group
Year: 2018
DOI identifier: 10.1038/s41467-018-06219-9
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