Abstract Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the people for this disease is age independent. However, sirtuins, which get activate typically during calorie restriction plays a pivotal role in optimizing effect of blood glucose levels in diabetic patients. Among different sirtuin homologs, some of the sirtuins are known for regulating pathophysiology of diabetic condition. Still the role of other sirtuins in understanding the function and regulatory mechanism in DM is still emerging. In this review, we focused on recent studies which help us to understand about the role of sirtuins and how they regulate the pathophysiology in diabetic condition
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