Article thumbnail

Sirtuins and diabetes: optimizing the sweetness in the blood

By Abhinav Kanwal and Liston Augustine Dsouza

Abstract

Abstract Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the people for this disease is age independent. However, sirtuins, which get activate typically during calorie restriction plays a pivotal role in optimizing effect of blood glucose levels in diabetic patients. Among different sirtuin homologs, some of the sirtuins are known for regulating pathophysiology of diabetic condition. Still the role of other sirtuins in understanding the function and regulatory mechanism in DM is still emerging. In this review, we focused on recent studies which help us to understand about the role of sirtuins and how they regulate the pathophysiology in diabetic condition

Topics: Sirtuins, Diabetes, Diseases, Mitochondria, Exercise, Deacetylation, Medicine, R
Publisher: BMC
Year: 2019
DOI identifier: 10.1186/s41231-019-0034-7
OAI identifier: oai:doaj.org/article:2b25145d9dc04152b40d91562a2c5e6b
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://link.springer.com/artic... (external link)
  • https://doaj.org/article/2b251... (external link)
  • https://doaj.org/toc/2396-832X (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.