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Chemical constituents from ethanol extract of Polyalthia rumphii branches and their cytotoxicity evaluation

By Tianshan Wang, Xiaopeng Wu, Yanping Liu, Youping Luo, Xiang Li, Yujie Zhou, AiPing Yang, Zhengmeng Yan, Ling Ye, Siwei Chen, Jinshuai Fu and Xianzhi Jiao


Twelve known compounds, including eight alkaloids, three lignans and one gossypol derivative, were isolated from the branches of Polyalthia rumphii (Blume ex Hensch.) Merr., Annonaceae. The chemical structures were determined by spectroscopic methods and comparison with literature data. All the isolates were evaluated the cytotoxicity against three human cancer cell lines: Hela, MCF-7 and A549, the results showed that partial of isolates displayed weak cytotoxicities with the IC50 values ranging from 25 to 40 μg/ml. Keywords: Alkaloids, Lignan, Gossypol derivative, Cytotoxic activity, Polyalthia rumphi

Topics: Pharmacy and materia medica, RS1-441
Publisher: Elsevier
Year: 2018
DOI identifier: 10.1016/j.bjp.2018.03.004
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