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Changes of inflammatory factors, reactive oxygen species and cognitive function in mice after brain-blast injury

By Ying Liu, Yun-En Liu, Chang-Ci Tong and Hong-Xu Jin

Abstract

Objective: To study the changes of cognitive function in mouse after brain-blast injury. Methods: Fourty healthy male C57BL/6 mice were randomly divided into model group and control group. After 24 h of injury, histopathological changesc and reactive oxygen species changes were observed under microscope; while changes of inflammatory cytokines content were determined by Western-blot. Four weeks later, Morris water maze method was used to detect the cognition impairment. Results: HE staining showed blast induced brain injury in C57BL/6 mice. Compared with normal control group, the expression of IL-1β,IL-4, IL-6 were significantly increased in brain tissue of model group whereas IL-10 was significantly decreased (P<0.05); ROS expression in the hippocampus of model group mice was significantly increased compared with that in the control group. Morris water maze showed cognition impairment in mice after brain-blast injury. Conclusions: Brain-blast injury causes cognition impairment in mice, which may be related to the occur of inflammatory change and oxidative stress in the early stage

Topics: Blast injury, Brain injury, Cognition impairment, Inflammation, Oxidative stress, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Publisher: Wolters Kluwer Medknow Publications
Year: 2018
DOI identifier: 10.4103/2221-6189.248025
OAI identifier: oai:doaj.org/article:fbae38d73d3242318fce9fadf4f0ada1
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