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Scheme for metabolites of 1a observed with human liver microsomes.

By Hao Sun (14095), David W. Piotrowski (1944802), Suvi T. M. Orr (1485076), Joseph S. Warmus (1997752), Angela C. Wolford (2004778), Steven B. Coffey (1463167), Kentaro Futatsugi (1399639), Yinsheng Zhang (321530) and Alfin D. N. Vaz (172262)

Abstract

<p>Scheme for metabolites of <u>1a</u> observed with human liver microsomes.</p

Topics: Biophysics, Biochemistry, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, version, drug pharmacokinetics II, 2 C 19, clearance deuterium isotope effect, pharmacokinetic enhancement, reaction mechanism influences outcome, results show, 3A, CYP, docking, pharmacokinetic parameters, profile, cytochrome P 450, Deuterium isotope effects, clearance deuterium isotope effects, clearance isotope effect, deuteration, chemotype
Year: 2018
DOI identifier: 10.1371/journal.pone.0206279.g004
OAI identifier: oai:figshare.com:article/7340723
Provided by: FigShare
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