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Flubendazole treatment causes pathology in female adult worms and uterine microfilariae.

By Marc P. Hübner (179253), Alexandra Ehrens (6236099), Marianne Koschel (4734597), Bettina Dubben (179259), Franziska Lenz (6236102), Stefan J. Frohberger (6236105), Sabine Specht (65641), Ludo Quirynen (6236090), Sophie Lachau-Durand (1834051), Fetene Tekle (6236093), Benny Baeten (6236096), Marc Engelen (149627), Charles D. Mackenzie (567517) and Achim Hoerauf (65649)

Abstract

<p>A, shown is the frequency of female adult worms presenting normal morphology (score 0, white bar), minor damage (score 1, green bar), significant damage (score 2, orange bar), extensive damage (score 3, red bar), or loss of content (score 4, purple bar). B, frequency of adult worms presenting no uterine microfilariae (score 0, purple bar), degenerated microfilariae (score 1, orange bar) or microfilariae with normal morphology (score 2, white bar) within the uteri. Adult worms were isolated 8 weeks post treatment end of jirds receiving oral gavages (OR) of flubendazole once (40mg/kg) or for five or ten consecutive days at 2, 6 or 15mg/kg or subcutaneous (SC) flubendazole injections once with 2mg/kg. The total number of female adult worms analyzed per group is indicated above each stacked bar.</p

Topics: Biochemistry, Molecular Biology, Physiology, Pharmacology, Immunology, Developmental Biology, Science Policy, Infectious Diseases, Virology, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, mg, adult worms, Litomosoides sigmodontis jird model, macrofilaricidal drug candidate, ASD, adult worm burden, SC treatment regimens, 5 SC injections, FBZ treatment regimens
Year: 2019
DOI identifier: 10.1371/journal.pntd.0006320.g004
OAI identifier: oai:figshare.com:article/7595057
Provided by: FigShare
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