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Additional file 15: of Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

By Mahmoud Mostafa (6286061), Christopher Rider (5864036), Suharsh Shah (686665), Suzanne Traves (6286064), Paul Gordon (136278), Anna Miller-Larsson (686666), Richard Leigh (293178) and Robert Newton (104105)


Pathways enriched in budesonide-regulated genes in airway epithelial cell variants and tissue were identified by Ingenuity Pathway Analysis. Budesonide-regulated genes ≥1.25 fold, or ≤ 0.8 fold (P ≤ 0.05), in A549 (1973 genes), BEAS-2B (3191 genes), HBE (1980 genes), and airway tissue (894 genes) were subjected to pathway analysis using Ingenuity Pathway Analysis (IPA). Pathways that were significantly enriched (−log P value ≥1.3; i.e. P ≤ 0.05) with any of the gene lists are shown. Enrichment (−log P value) is shown in purple and z-score is shown in red for positive values (activation) or in blue for negative values (inhibition). (XLSX 54 kb

Topics: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Physiology, Pharmacology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Glucocorticoid, Inhaled corticosteroid (ICS), Airway epithelium, Transactivation, Transrepression, Asthma
Year: 2019
DOI identifier: 10.6084/m9.figshare.7659134.v1
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Provided by: FigShare
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