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Brain and blood methylation comparison.

By Marlene Lorgen-Ritchie (6288887), Alison D. Murray (499809), Anne C. Ferguson-Smith (127005), Marcus Richards (306829), Graham W. Horgan (438121), Louise H. Phillips (6288890), Gwen Hoad (363659), Ishbel Gall (6288893), Kristina Harrison (6288896), Geraldine McNeill (107695), Mitsuteru Ito (6288899) and Paul Haggarty (363657)

Abstract

<p>DNA methylation in the imprints <i>H19ICR</i>, <i>IGF2</i>, <i>IG-DMR</i>, <i>KvDMR</i>, <i>MEST1</i>, <i>NESPAS</i>, <i>PEG3</i>, <i>SNRPN</i> and <i>ZAC1</i> in blood from ABC36 (n = 485) and five selected regions from four brains sampled post-mortem (AH: Anterior Hippocampus. BG: Basal ganglia. PH: Posterior Hippocampus. PWM: Periventricular white matter. TH: Thalamus). The individual methylation values for each brain sample are shown with cases (individuals with evidence of Alzheimer’s Disease) represented by open circles and controls (no apparent neurodegeneration beyond that expected for age) by closed circles. The population distribution of methylation levels in blood are shown on the same methylation scale.</p

Topics: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Developmental Biology, Science Policy, Mental Health, Hematology, Infectious Diseases, adult blood, IG-DMR, ability Genomic imprinting, ZAC, MEST 1, 7 q 31-34 regions, NESPAS, IGF, methylation, PEG, CI, Aberdeen Brain Bank, maternally methylated genes SNRPN, 15 q 11-q
Year: 2019
DOI identifier: 10.1371/journal.pone.0211799.g001
OAI identifier: oai:figshare.com:article/7662881
Provided by: FigShare
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