Article thumbnail

P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation – The CONTEXT study

By Marie B. Nielsen (6411161), Nicoline V. Krogstrup (6411164), Gertrude J. Nieuwenhuijs-Moeke (5518805), Mihai Oltean (6411167), Frank J. M. F. Dor (283158), Bente Jespersen (550700) and Henrik Birn (174805)

Abstract

<div><p>Background</p><p>Early markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.</p><p>Methods</p><p>225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).</p><p>Results</p><p>All biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early biomarker levels and mGFR or eGFR at three or twelve months.</p><p>Conclusion</p><p>High plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.</p><p>Trial registration</p><p>ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT01395719" target="_blank">NCT01395719</a></p></div

Topics: Biochemistry, Medicine, Cell Biology, Physiology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, graft function, CONTEXT study Background, donor kidney transplant recipients, mGFR, tCr, urine output, year graft function, biomarker levels, ability, YKL, eGFR, Conclusion High plasma NGAL, transplantation, Day 1, DGF, ELISA, AUC, L-FABP, P-NGAL Day 1, kidney graft function, Day 5. Plasma NGAL, GFR, NCT
Year: 2019
DOI identifier: 10.1371/journal.pone.0212676
OAI identifier: oai:figshare.com:article/7787084
Provided by: FigShare
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://clinicaltrials.gov/ct2... (external link)
  • https://figshare.com/articles/... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.