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Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female <i>Ldlr <sup>-/-</sup></i> mice - Fig 9

By Manuel Garcia-Jaramillo (6551930), Melinda H. Spooner (6551933), Christiane V. Löhr (418937), Carmen P. Wong (512550), Weijian Zhang (446407) and Donald B. Jump (498480)


<p>Western diet effects on the expression of enzymes involved in complex lipid synthesis (A) and TG catabolism (B). Transcript abundance was quantified as described above. Results are expressed as mRNA abundance, Fold Change; mean ± SEM, N = 7–8 samples, *, FDR < 0.05 versus the RD46 group. [<b>A</b>: Gly Kin, glycerokinase; Gpatm, glycerophosphate acyltransferase-mitochondrial; Dgat, diacylglycerol acyl transferase; LpCat, lysophosphatidyl choline acyltransferase; Crls, cardiolipin synthase; Taf, tafazzin; SpTlc, serine palmitoyl transferase long chain; Sgms, sphingomyelin synthase]; [<b>B</b>: Atgl, adipocyte triglyceride lipase, Ces1g, carboxyesterase-1g; Tgh, triglyceride hydrolase/Ces3].</p

Topics: Biochemistry, Microbiology, Cell Biology, Genetics, Biotechnology, Marine Biology, Virology, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, lipidomic, 2C, SFA, Conclusion WD-induced NASH, hepatic pro-inflammatory oxylipins, transcriptomic, HCC, 1004A, expression, lipid markers, 1A, liver disease, C 18-22 PUFA-containing membrane lipids, NAFLD, MUFA, hepatic abundance, PGE, Ldlr, C 18-22 PUFA-containing phosphoglycerolipids, TNF, diet-induced nonalcoholic steatohepatitis
Year: 2019
DOI identifier: 10.1371/journal.pone.0214387.g009
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Provided by: FigShare
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