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By Gabriele Sass (335744), Shajia R. Ansari (6681221), Anna-Maria Dietl (5205830), Eric Déziel (45393), Hubertus Haas (194198) and David A. Stevens (337310)


<p>In need for iron <i>P</i>. <i>aeruginosa</i> (Pa) produces its siderophore pyoverdine (PYOV). PYOV-chelated iron is not available to <i>A</i>. <i>fumigatus</i> (Af), resulting in iron deficiency and damage to the fungus. Anti-fungal activity in part is counter-balanced by SidA-dependent <i>A</i>. <i>fumigatus</i> hydroxamate siderophores, providing iron to the fungus, further denying iron from <i>P</i>. <i>aeruginosa</i>.</p

Topics: Medicine, Microbiology, Ecology, Immunology, Hematology, Infectious Diseases, Virology, Astronomical and Space Sciences not elsewhere classified, Biological Sciences not elsewhere classified, fumigatus biofilms, aeruginosa supernatants, fumigatus siderophores, iron chelator deferiprone, Aspergillus fumigatus siderophores, Pseudomonas aeruginosa Pseudomonas aeruginosa, co-inhabiting immunocompromised patient airways, Af Δ sidA biofilm, DFP, fumigatus siderophore production inhibitor celastrol, fumigatus planktonic supernatants, aeruginosa siderophore pyoverdine, fumigatus hydroxamate siderophores, fumigatus biofilm
Year: 2019
DOI identifier: 10.1371/journal.pone.0216085.g007
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Provided by: FigShare
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