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Toward fully fledged high-pressure macromolecular crystallography

By Eric Girard, Anne-Claire Dhaussy, Bernard Couzinet, Jean-Claude Chervin, Mohamed Mezouar, Richard Kahn, Isabella Asconea and Roger Fourme

Abstract

International audiencePressure allows one to explore the energy landscape and the various conformations of macromolecules. This might be one of the most interesting prospects of combining macromolecular crystallography (MX) with pressure perturbation. This paper presents innovations in high-pressure macromolecular crystallography (HPMX). A new-generation diamond anvil cell extends the technical feasibility of HPMX experiments up to about 2.5 GPa (depending on the sample). Thanks to the large useful aperture (8

Topics: [PHYS.COND.CM-GEN]Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other]
Publisher: 'International Union of Crystallography (IUCr)'
Year: 2007
DOI identifier: 10.1107/S0021889807033833
OAI identifier: oai:HAL:hal-00194410v1
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