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The cocktail approach and its utility in drug-drug interaction assessments for therapeutic proteins

By Alexander Jetter and Uwe Fuhr

Abstract

This chapter demonstrates that the cocktail approach is suitable for the study of interactions between therapeutic proteins and drugs in humans—namely for the study of the effect of therapeutic proteins on cytochrome P450 enzyme activities.This is the area in which the FDA's current draft guideline on drug interaction studies recommends the use of cocktail phenotyping studies as an alternative to individual therapeutic protein–drug interaction studies

Topics: Clinic for Clinical Pharmacology and Toxicology, 610 Medicine & health
Publisher: John Wiley & Sons
Year: 2013
DOI identifier: 10.1002/9780470571224.pse478
OAI identifier: oai:www.zora.uzh.ch:93482
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