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Effect of inflammation on local expression of 11β-HSD1

By Pavlína Kvapilová


Inflammation is first-line host defense mechanism of organism that aims to remove unwanted pathogens, repair damaged tissue and restore homeostasis. Glucocorticoids belong to effective immune response regulators. Their availibility in the tissue is due to several factors, including local metabolism in the cell that provide 11β-hydroxysteroid dehydrogenase enzymes. We know two isoforms 11HSD1 and 11HSD2. 11HSD1 locally in the cell catalyzes the conversion of the inactive glucocorticoid molecule to active, and thus appears to be a significant player in regulating the inflammatory response. The aim of this work was to analyze gene expression of 11HSD1 together with expression of cytokines in specific microanatomical compartments of the immune system involved in immune response to experimental DSS colitis. Keywords Metabolism of glucocorticoids; Cytokine microenvironment; Lymphoid organs; Colon; Dextran-sodium-sulfate coliti

Year: 2018
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