Intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy

Abstract

Patients with a chronic inflammatory demyelinating polyneuropathy (CIDP) may respond to \ntreatment with corticosteroids and to plasmapheresis, which was demonstrated in controlled \nclinical studies. In an uncontrolled study it was found that 13/17 CIDP patients had a rapid and clinical \nimportant improvement after infusion of Fresh Frozen Plasma (FFP). A beneficial response was \nalso seen after-mtravenous rmmunoglobulin (Mg) treatment. \nThe aims of this study were: \n- to evaluate the clinical effectiveness of Mg in CIDP patients, \n- to define clinical and inrmunological factors associated with improvement after Mg in CIDP \npatients and - to investigate immunological mechanisms involved in the response to Mg treatment