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Development of functional assays for p97/VCP inhibition

By Yihui Shi, Xiaohe Liu, Joy Calaoagan, Steven Samuelson, Tsui-Fen Chou, Raymond J. Deshaies and Lidia C. Sambucetti

Abstract

p97 (also called VCP in metazoans and CDC48 in yeast) is a highly conserved, ubiquitously expressed, and essential AAA ATPase. p97 plays a key role in endoplasmic reticulum-associated degradation of misfolded secretory and membrane proteins as well as ubiquitin-dependent turnover of a subset of cytoplasmic substrates of the ubiquitin-proteasome system

Publisher: American Association for Cancer Research
Year: 2013
OAI identifier: oai:authors.library.caltech.edu:44489
Provided by: Caltech Authors
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