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Transition-Metal-Catalyzed Propargylic Substitution

By N. Ljungdahl and Nina Kann

Abstract

(Chemical Equation Presented) Keen for a share in the glory: Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper-catalyzed asymmetric propargylic amination reactions. Nu = nucleophile \ua9 2009 Wiley-VCH Verlag GmbH & Co. KGaA

Topics: Physical Chemistry, Chemical Sciences, acetates, alkylation, transition metals, propargylic, amination, nucleophilic substitution, asymmetric catalysis, complexes, alkynes, amines, enoxysilanes, alcohols, esters, nucleophilic-substitution, substitution, acetone
Publisher: 'Wiley'
Year: 2009
DOI identifier: 10.1002/anie.200804114
OAI identifier: oai:research.chalmers.se:107261
Provided by: Chalmers Research
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