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Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract

By Hong Cai, Sarah C. Thomasset, David P-. Berry, Giuseppe Garcea, Karen Brown, William P. Steward and Andreas J. Gescher


This paper was published as Biomedical Chromatography, 2011, 25 (6), pp. 660-663. It is available from DOI: 10.1002/bmc.1499Metadata only entryAnthocyanins possess cancer chemopreventive properties in preclinical models. Their clinical pharmacology is only poorly understood. In this pilot study, anthocyanins and their metabolites were analysed in the urine of two patients with colorectal liver metastases. They received a single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver resection. HPLC-MS/MS and HPLC-UV analysis showed there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum. This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption

Topics: anthocyanins, adsorption, metabolites, human urine
Publisher: Wiley-Blackwell
Year: 2010
DOI identifier: 10.1002/bmc.1499
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