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Translational Profiling of Chronic Lymphocytic Leukaemia

By Helen Rogers


B cell chronic lymphocytic leukaemia (B-CLL) is the most common form of adult leukaemia in the western world, characterised by the slow accumulation of small mature B lymphocytes in the circulating blood. Disease progression is prolonged and patients may survive for more than 20 years, however it ultimately remains incurable with conventional chemotherapy.\ud Regulation of gene expression is a complex process and exerted at multiple steps in the expression pathway, including translation. Translational regulation has not previously been studied in B-CLL yet may be important as there are numerous examples of translation de-regulation in tumorigenesis. Results obtained suggest that a reduced level of protein synthesis was occurring in B-CLL cells. Furthermore, cDNA microarray analysis was performed providing a gene expression profile at the level of translation, which correlates with the biology of the disease.\ud Internal ribosome entry could be a possible mechanism of up-regulation utilised, and evidence is provided to suggest this may be the case. Potential IRES activity was observed for three genes, found to be translationally up-regulated in B-CLL cells by the cDNA microarray analysis, under normal and serum starvation conditions.\ud The microarray data provides some potential new targets for treatment. In particular, the up-regulation of the angiotensin II type 1 receptor may influence survival of B-CLL cells. Initial evidence suggests that its ligand angiotensin II could influence B-CLL cell survival.\ud Median survival of B-CLL patients is 10 years, however disease progression is variable; some patients will survive for many years while others have a more aggressive form and die within a couple of years. Progression has been observed to correlate with the mutational status of the immunoglobulin heavy chain variable (IgVH) genes. Differences in polysome association for the two subtypes were determined, using the microarray data obtained, identifying a number of genes that may be significant to the biology of the disease

Publisher: University of Leicester
Year: 2005
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  2. (2000). A cell cycle-dependent internal ribosome entry site. "
  3. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. "
  4. (1991). A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8; 12)(g24; q22) translocation in a case of B-cell chronic lymphocytic leukemia. "
  5. (1985). A Drosophila-Minute Gene Encodes A RibosomalProtein. "
  6. (1996). A highly efficacious lymphocyte chemoattractant, stromal cell- derived factor 1 (SDF-1). "
  7. (2000). A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: A novel mechanism of oncogene de-regulation. " Oncogene
  8. (1991). A New Perspective On Ornithine Decarboxylase Regulation - Prevention Of Polyamine Toxicity Is The Overriding Theme. "
  9. (1981). A New Prognostic Classification Of Chronic Lymphocytic-Leukemia Derived From A Multivariate Survival Analysis. "
  10. (1997). A new translational regulator with homology to eukaryotic translation initiation factor 4G. "
  11. (2000). A novel form of DAPS protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site- mediated translation. "
  12. (1997). A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. "
  13. (2001). A potential role of nuclear matrix-associated protein kinase CK2 in protection against drug-induced apoptosis in cancer cells. "
  14. (1996). A reevaluation of the cap-binding protein, eIF4E, as a rate- limiting factor for initiation of translation in reticulocyte lysate. "
  15. (1994). A Revised European-American Classification Of Lymphoid Neoplasms -A Proposal From The International Lymphoma Study- Group. "
  16. (1988). A Segment Of The 5' Nontranslated Region Of Encephalomyocarditis Virus-Rna Directs Internal Entry Of Ribosomes During Invitro Translation. "
  17. (2003). A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. "
  18. (2003). A single internal ribosome entry site containing aG quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons. "
  19. (2001). A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. "
  20. (2000). Aberrant B cell receptor signaling from B29 (Ig beta, CD79b) gene mutations of chronic lymphocytic leukemia B cells. "
  21. (1991). Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. "
  22. (1996). Aberrant translational control of the c-myc gene in multiple myeloma. "
  23. (1997). Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia. "
  24. (1995). Abrogation Of Translation Initiation-Factor Eif-2 Phosphorylation Causes Malignant Transformation Of Nih 3t3 Cells. "
  25. (1994). Activation Of A Tumor-Associated Proteinnase (P4o(Tak)) And Casein Kinase-2 In Human Squamous-Cell Carcinomas And Adenocarcinomas Of The Lung. "
  26. (1983). Activation of the c-myc gene by translocation: a model for translational control. "
  27. (1990). Activity Of Protein Phosphatases Against Initiation Factor-Ii And Elongation Factor-li. "
  28. (1999). Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. "
  29. (1996). Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. "
  30. (1998). Altered pattern of cytokine production by peripheral blood CD2+ cells from B chronic lymphocytic leukemia patients. "
  31. (1995). Alternative Splicing Of Cd79a (Ig-Alpha/Mb1) And Cd79b (Ig- Beta/B29) Rna Transcripts In Human B-Cells. "
  32. (2002). Alternatively spliced forms of Ig alpha and Ig beta prevent B cell receptor expression on the cell surface. "
  33. (1995). Alternatively spliced human type I angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms. "
  34. (1999). An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia. "
  35. (1991). An Analysis Of Vertebrate Messenger-Rna Sequences -
  36. (1997). Analysis of blood T-cell cytokine expression in Bchronic lymphocytic leukaemia: Evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells. "
  37. (2000). Analysis of the c-myc IKES; a potential role for cell-type specific trans-acting factors and the nuclear compartment. "
  38. (2002). Ancient pathways programmed by small RNAs. "
  39. (2000). Angiotensin II activates nuclear transcription factor kappa B through AT(1) and AT(2) in vascular smooth muscle cells - Molecular mechanisms. "
  40. (2002). Angiotensin II activates nuclear transcription factorkappa B through AT(1) and AT(2) receptors. "
  41. (1999). Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes. "
  42. (2004). Angiotensin II attenuates NMDA receptormediated neuronal cell death and prevents the associated reduction in Bcl-2 expression. "
  43. (1997). Angiotensin II induces apoptosis of human endothelial cells - Protective effect of nitric oxide. "
  44. (1993). Angiotensin II receptors and angiotensin II receptor antagonists. "
  45. (2001). Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes. "
  46. (1996). Angiotensin II type 2 receptor mediates programmed cell death. "
  47. (1995). Antigen Receptor Nonresponsiveness In Chronic Lymphocytic- Leukemia B-Cells. "
  48. (1998). Apoptosis in B-chronic lymphocytic leukaemia. "
  49. (1993). Association Of A 70-Kda Tyrosine Phosphoprotein With The Cd16- Zeta-Gamma Complex Expressed In Human Natural-Killer-Cells. "
  50. (1987). At Least 6 Nucleotides Preceding The Aug Initiator Codon Enhance Translation In Mammalian-Cells. "
  51. (2002). Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.
  52. (1999). ATM mutations in B-cell chronic lymphocytic leukemia. "
  53. (1993). Autocrine release of angiotensin II mediates stretchinduced hypertrophy of cardiac myocytes in vitro. "
  54. (2002). Autologous and allogeneic stem cell transplantation for chronic lymphocytic leukemia. "
  55. (2001). B cell development pathways. "
  56. (1997). B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. "
  57. (1999). B-cell chronic lymphocytic leukemia: A bird of a different feather. "
  58. (1996). B-chronic lymphocytic leukemia: A malignancy of anti-self B cells. "
  59. (1996). Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. "
  60. (1999). Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. "
  61. (1993). Bcl-2 Gene Hypomethylation And High-Level Expression In B-Cell Chronic Lymphocytic-Leukemia. "
  62. (1988). Bcl-2 Gene Promotes Hematopoietic-Cell Survival And Cooperates With C-Myc To Immortalize Pre-B-Cells. "
  63. (1993). Bcl-2 Heterodimerizes In-Vivo With A Conserved Homolog, Bax, That Accelerates Programmed Cell-Death. "
  64. (2004). BCL-2 translation is mediated via internal ribosome entry during cell stress. "
  65. (1997). Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. "
  66. (2000). Biology of chronic lymphocytic leukemia. "
  67. (1998). Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: Prevalence of latent STAT1 in highmolecular weight complexes. "
  68. (1999). BLNK required for coupling Syk to
  69. (1998). BLNK: a central linker protein in B cell activation. "
  70. (2000). Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. "
  71. (1999). Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia. "
  72. (1992). BTG1, a member of a new family of antiproliferative genes. "
  73. (1998). C-Myc 5 'untranslated region contains an internal ribosome entry segment. "
  74. (2000). c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. "
  75. (2000). cAMP-mediated growth inhibition of lymphoid cells in G1: rapid down-regulation of cyclin D3 at the level of translation. "
  76. (1992). Cancer - P53, Guardian Of The Genome. "
  77. (1988). Cap Recognition And The Entry Of Messenger-Rna Into The Protein-Synthesis Initiation Cycle. " Trends In
  78. (1998). Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites. "
  79. (1999). Caspase activation involves the formation of the aposome, a large (similar to 700 kDa) caspase-activating complex. "
  80. (2000). Caspase-3-dependent and -independent degradation of 28 S ribosomal RNA may be involved in the inhibition of protein synthesis during apoptosis initiated by death receptor engagement. "
  81. (1997). CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. "
  82. (2002). CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia. "
  83. (2002). CD38 expression does not change in B-cell chronic lymphocytic leukemia. "
  84. (2002). CD38 expression in B-cell chronic lymphocytic leukemia: association with clinical presentation and outcome in 155 patients. "
  85. (2001). CD38 expression is a poor predictor for V-H gene mutational status and prognosis in chronic lymphocytic leukemia. "
  86. (2002). CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia. "
  87. (2001). cDNA microarray gene expression analysis of Bcell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking. "
  88. (2001). Cell cycle regulatory proteins and apoptosis in Bcell chronic lymphocytic leukemia. "
  89. (1996). Cell growth arrest and induction of cyclindependent kinase inhibitor p21(WAF1/CIP1) mediated by STAT1. "
  90. (2004). Cellular internal ribosome entry segments: structures, trans- acting factors and regulation of gene expression. "
  91. (1999). Chlorambucil resistance in B-cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl2-expressing subclones. "
  92. (1994). Chromatographic Resolution Of In-Vivo Phosphorylated And Nonphosphorylated Eukaryotic Translation Initiation-Factor Eif- 4e -Increased Cap Affinity Of The Phosphorylated Form. "
  93. (1997). Chromosome aberrations in atypical chronic lymphocytic leukemia: a cytogenetic and interphase cytogenetic study. "
  94. (2002). Chronic B cell malignancies and bone marrow microenvironment. "
  95. (1997). Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. "
  96. (1999). Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. "
  97. (2004). Chronic lymphocytic leukemia: revelations from the B-cell receptor. "
  98. (1998). Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. "
  99. (1998). Circularization of mRNA by eukaryotic translation initiation factors. "
  100. (1975). Clinical Staging Of Chronic Lymphocytic Leukemia. "
  101. (2000). Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2 alpha kinase: Down-regulated in epithelial ovarian cancers. "
  102. (1990). Cobalamin-Dependent Methionine Synthase. "
  103. (1997). Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. "
  104. (1974). Comparison Of Normal And Cll Lymphocyte Surface Ig Determinants Using Peroxidase-Labeled Antibodies. 1. Detection And Quantitation Of Light Chain Determinants. "
  105. (1989). Context Effects And Inefficient Initiation At Non-Aug Codons In Eukaryotic Cell-Free Translation Systems. "
  106. (2002). Control of eukaryotic protein synthesis by upstream open reading frames in the 5 '-untranslated region of an mRNA. "
  107. (2003). CXCR4 and SDF-1 expression in B-cell chronic lymphocytic leukemia and stage of the disease. "
  108. (2003). Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation. "
  109. (1998). Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase Akt-dependent pathway. "
  110. (1999). Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines. "
  111. (2002). Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. " Cell 109: S 121-S 131.
  112. (1995). Cytotoxicity-Dependent Apo-1 (Fas/Cd95)-Associated Proteins Form A Death-Inducing Signaling Complex (Disc) With The Receptor. "
  113. (2002). Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia. "
  114. (1997). Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. "
  115. (2002). Degradation of cellular mRNA is a general early apoptosis-induced event. "
  116. (1988). Depletion Of Saccharomyces-Cerevisiae Ribosomal Protein-L16 Causes A Decrease In 60s Ribosomal-Subunits And Formation Of Half-Mer Polyribosomes. "
  117. (2001). Derivation of a Structural model for the cmyc IKES. "
  118. (1998). Detailed molecular delineation of 13g14.3 loss in B-cell chronic lymphocytic leukemia. "
  119. (1987). Developmental genetics of ribosome synthesis in Drosophila. "
  120. (2001). Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C-elegans. "
  121. (1985). Differential Efficiencies Of Invitro Translation Of Mouse C-Myc Transcripts Differing In The 5' Untranslated Region. "
  122. (2001). Differential expression of chemokine receptors in B cell malignancies. "
  123. (1997). Differential rates of somatic hypermutation in V-H genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. "
  124. (2003). Differential signaling via surface 1gM is associated with V-H gene mutational status and CD38 expression in chronic lymphocytic leukemia. "
  125. (2004). Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation. "
  126. (1999). Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. "
  127. (1996). Differentiation of NG108-15 neuroblastoma cells by serum starvation or dimethyl sulfoxide results in marked differences in angiotensin II receptor subtype expression. "
  128. (1995). Direct Stimulation Of Jak/Stat Pathway By The Angiotensin-Ii At(1) Receptor. "
  129. (1991). Directions For Polyamine Research. "
  130. (1980). Discrimination Of Human-Leukemia Subtypes By Flow Cytometric Analysis Of Cellular Dna And Rna. "
  131. (1998). Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. "
  132. (2000). Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. "
  133. (2002). Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia. "
  134. (1997). DNA methylation changes in hematologic malignancies: Biologic and clinical implications. "
  135. (2002). DNA methylation in cancer: too much, but also too little. "
  136. (2002). Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? "
  137. (2002). DUG is a novel homologue of translation initiation factor 4G that binds eIF4A. "
  138. (1995). Effect Of Interleukins On The Proliferation And Survival Of B- Cell Chronic Lymphocytic-Leukemia Cells. "
  139. (1999). eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation. "
  140. (1997). eIF4G: A multipurpose ribosome adapter? (vol 275, pg 500,
  141. (1997). eIF4G: Translation's mystery factor begins to yield its secrets. "
  142. (1996). Elevated protein kinase CK2 activity in chromatin of head and neck tumors: Association with malignant transformation. "
  143. (2003). Emerging and diverse roles of protein kinase C in immune cell signalling. "
  144. (1994). Enhanced Translation -A Novel Mechanism Of Mdm2 Oncogene Overexpression Identified In Human Tumor-Cells. "
  145. (1988). Erythroid-Differentiation Factor Is Encoded By The Same Messenger-Rna As That Of The Inhibin Beta-A Chain. "
  146. (2003). Estrogen regulates adrenal angiotensin AT(l) receptors by modulating AT(1) receptor translation. "
  147. (1991). Eukaryotic Initiation Factor-Eif-2 And FactorEif-3 - Interactions, Structure And Localization In Ribosomal Initiation-Complexes. "
  148. (1991). Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. "
  149. (1992). Evidence For The Participation Of Endogenous Activin-A Erythroid-Differentiation Factor In The Regulation Of Erythropoiesis. "
  150. (2001). Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia. "
  151. (1998). Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses. "
  152. (1995). Expression of cell cycle regulatory proteins in chronic lymphocytic leukemias. Comparison with non-Hodgkin's lymphomas and nonneoplastic lymphoid tissue. "
  153. (2004). Expression of cyclin E in resting and activated Bchronic lymphocytic leukaemia cells: cyclin E/cdk2 as a potential therapeutic target. "
  154. (2003). Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia. "
  155. (1999). Expression of the eukaryotic translation initiation factors 4E and 2 alpha in non-Hodgkin's lymphomas. "
  156. (1996). Expression of the immunoglobulin-associated protein B29 in B cell disorders with the monoclonal antibody SN8 (CD79b). "
  157. (2002). Expression of ZAP-70 is associated with increased Bcell receptor signaling in chronic lymphocytic leukemia. "
  158. (2002). Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells. " Carcino eg nesis
  159. (1999). FISH analysis for BCL-1 rearrangements and trisomy 12 helps the diagnosis of atypical B cell leukaemias. "
  160. (1997). FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). "
  161. (2002). Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13g14 in chronic lymphocytic leukemia. "
  162. (1990). Functional-Properties Of Phosphorylated Elongation Factor-Ii. "
  163. (2003). Gene expression dynamics during germinal center transit in B cells. Immune Mechanisms And Disease.
  164. (2001). Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. "
  165. (2001). Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C-elegans developmental timing. "
  166. (2002). Genetics of chronic lymphocytic leukemia: genomic aberrations and V-H gene mutation status in pathogenesis and clinical course. "
  167. (2004). Genistein affests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p2I(wafl/cipl) and Weel. "
  168. (2001). Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. " Oncogene
  169. (2000). Herne-regulated eIF2a kinase.
  170. (2004). hnRNP K enhances insulin-induced expression of mitochondrial UCP2 protein. "
  171. (1998). How cells respond to interferons. "
  172. (2001). Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct. "
  173. (1997). Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. "
  174. (1999). Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnkl to phosphorylate eIF4B. "
  175. (2001). Identification and characterization of functional angiotensin II type I receptors on immortalized human fetal aortic vascular smooth muscle cells. " Molecular And Cellular Endocrinology 183(1-2):
  176. (2003). Identification of a global gene expression signature of B- chronic lymphocytic leukemia. "
  177. (1999). Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. "
  178. (1991). Identification of mRNAs associated with programmed cell death in immature thymocytes. "
  179. (1987). Identification Of The Major-Mr 100,000 Substrate For Calmodulin-Dependent Protein Kinase-Iii In Mammalian-Cells As Elongation FactorIi. "
  180. (1999). Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. "
  181. (1999). IL4 production and increased CD30 expression by a unique CD8(+) T-cell subset in B-cell chronic lymphocytic leukaemia. "
  182. (2003). Immunobiology of chronic lymphocytic leukemia. "
  183. (1996). Immunodeficiency in protein kinase cbeta-deficient mice. "
  184. (1987). Importance Of Fsh-Releasing Protein And Inhibin In Erythrodifferentiation. "
  185. (1985). Improved M13 Phage Cloning Vectors And Host Strains - Nucleotide-Sequences Of The M13mp18 And Puc19 Vectors. "
  186. (2000). In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-adenosylmethionine decarboxylase. "
  187. (2003). In: Translational Control of Gene Expression.
  188. (1994). Inactivation Of A Cdk2 Inhibitor During Interleukin 2-Induced Proliferation Of Human T-Lymphocytes. "
  189. (1999). Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. "
  190. (1998). Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells. "
  191. (1993). Independent Regulation Of Human D-Type Cyclin Gene-Expression During G1-Phase In Primary Human Lymphocytes-T. "
  192. (1980). Individual Cell-By-Cell Quantitation Of Lymphocyte Surface- Membrane Ig In Normal And Cll Lymphocytes And During Ontogeny Of Mouse Lymphocytes-B By Immunoperoxidase Assay. "
  193. (2004). Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis. "
  194. (1996). Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells. "
  195. (1998). Inhibition of Statt-mediated gene activation by PIAS 1. "
  196. (2002). Initiation factor eIF5B catalyzes second GTPdependent step in eukaryotic translation initiation. "
  197. (1999). Initiation of translation in prokaryotes and eukaryotes. "
  198. (1994). Insulin-Dependent Stimulation Of ProteinSynthesis By Phosphorylation Of A Regulator Of 5'-Cap Function. "
  199. (1996). Integrin function in chronic lymphocytic leukemia. "
  200. (1993). Interferon Gamma Inhibits Apoptotic Cell-Death In B-Cell Chronic Lymphocytic-Leukemia. "
  201. (1993). Interferon-Gamma Arrests Proliferation And Causes Apoptosis In Stromal Cell Interleukin-7-Dependent Normal Murine Pre-B-Cell Lines And Clones Invitro, But Does Not Induce Differentiation To Surface Immunoglobulin-Positive B-Cells. "
  202. (2001). Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8(+) T cells from B-CLL patients: impact on clonal B-cell apoptosis. "
  203. (1993). Interleukin-2 Prevents Programmed Cell-Death In Chronic Lymphocytic-Leukemia Cells. "
  204. (1992). Interleukin-4 Protects Chronic Lymphocytic Leukemic B-Cells From Death By Apoptosis And Up-Regulates Bcl-2 Expression. "
  205. (1995). Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond. "
  206. (1988). Internal Initiation Of Translation Of Eukaryotic Messenger-Rna Directed By A Sequence Derived From Poliovirus Rna. "
  207. (2001). Internal ribosome entry sites in eukaryotic mRNA molecules. "
  208. (2000). International union of pharmacology. XXIII. The angiotensin II receptors. "
  209. (1991). Intraclonal generation of antibody mutants in germinal centres. "
  210. (2001). Involvement of chemokine receptors in breast cancer metastasis. "
  211. (2000). Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors? " Seminars In
  212. (2002). Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. "
  213. (1994). Iron Regulatory Protein Prevents Binding Of The 43s Translation Pre-Initiation Complex To Ferritin And Ealas Messenger-Rnas. "
  214. (1998). IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex e1F4F. "
  215. (1995). Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. "
  216. (2002). Joining the cell survival squad: an emerging role for protein kinase CK2. " Trends In
  217. (2004). L-Myc protein synthesis is initiated by internal ribosome entry. "
  218. (1990). Malignant Transformation By A Eukaryotic Initiation-Factor Subunit That Binds To Messenger-Rna 5' Cap. "
  219. (2002). mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. "
  220. (2000). Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy. "
  221. (2004). MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family. "
  222. (2000). Mechanism and regulation of initiator methionyl tRNA binding to ribosomes. In
  223. (1993). Mechanism of action and regulation of protein synthesis initiation factor 4E: effects on mRNA discrimination, cellular growth rate, and oncogenesis. "
  224. (1999). Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. "
  225. (2002). Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. "
  226. (2001). Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy. "
  227. (2004). Melanoma differentiation-associated gene-7/IL-24 al Of gene enhances NF-KB activation and suppresses apoptosis induced by TNF. "
  228. (2004). MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. "
  229. (2003). Mnkl is required for angiotensin II - Induced protein synthesis in vascular smooth muscle cells. "
  230. (2000). Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. "
  231. (1993). Molecular Characterization Of Angiotensin-IiInduced Hypertrophy Of Cardiac Myocytes And Hyperplasia Of Cardiac Fibroblasts -Critical Role Of The At(1) Receptor Subtype. "
  232. (1998). Molecular evidence for the critical role of the stroma in regulation of hemopoiesis: Stromal activin a restricts B cell lymphopoiesis. "
  233. (1999). Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and survival. "
  234. (1994). Molecular-Cloning And Structure Of A Pre-BCell Growth- Stimulating Factor. "
  235. (2002). Multiple cell cycle regulator alterations in Richter's transformation of chronic lymphocytic leukemia. "
  236. (1995). Multiple patterns of MDM-2 deregulation in human leukemias: implications in leukemogenesis and prognosis. " Leuk Lymphoma 17(1-2):
  237. (2000). NF-kappaB inhibition ameliorates angiotensin IIinduced inflammatory damage in rats. "
  238. (1993). Nonlinear Ribosome Migration On Cauliflower Mosaic Virus-35s Rna. "
  239. (1997). Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells. "
  240. (1994). Nuclear Casein Kinase-2 (Ck-2) Activity In Human Normal, Benign Hyperplastic, And Cancerous Prostate. "
  241. (2003). Nutritional modulation of gene expression and homocysteine utilization by vitamin B-12. "
  242. (2003). One-thousand-and-one substrates of protein kinase CK2? "
  243. (1995). Overexpression of cyclin D2 in chronic B-cell malignancies. "
  244. (1990). Overexpression Of Eukaryotic ProteinSynthesis Initiation Factor-4e In Hela-Cells Results In Aberrant Growth And Morphology. "
  245. (1998). Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells. "
  246. (1999). Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1). "
  247. (1994). P27, A Novel Inhibitor Of GI Cyclin-Cdk ProteinKinase Activity, Is Related To P21. "
  248. (1997). p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis. "
  249. (2000). p53 binds selectively to the 5' untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor beta- and p53-mediated translational inhibition of cdk4. " Molecular And Cellular Biology
  250. (2001). p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. "
  251. (1998). p53 expression in B-cell chronic lymphocytic leukemia: A marker of disease progression and poor prognosis. "
  252. (1995). P53 Gene Deletion Predicts For Poor Survival And Nonresponse To Therapy With Purine Analogs In Chronic B-Cell Leukemias. "
  253. (1994). P53 Mutations Are Associated With Resistance To Chemotherapy And Short Survival In Hematologic Malignancies. "
  254. (1991). P53 Mutations In Human Cancers. "
  255. (1991). P53 Mutations In Human Lymphoid Malignancies - Association With Burkitt-Lymphoma And Chronic Lymphocytic-Leukemia. "
  256. (1995). P53-Dependent Repression Of Cdk4 Translation
  257. (1997). p53, the cellular gatekeeper for growth and division. "
  258. (1996). p53: Puzzle and paradigm. "
  259. (2004). Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II. "
  260. (1995). Perinatal Lethality And Blocked B-Cell Development In Mice Lacking The Tyrosine Kinase Syk. "
  261. (2002). Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with highdose chlorambucil. "
  262. (2000). PERK and translational control by stress in the endoplasmic reticulum. In
  263. (1995). Phosphorylated Immunoreceptor Signaling Motifs (Itams) Exhibit Unique Abilities To Bind And Activate Lyn And Syk Tyrosine Kinases. "
  264. (2002). Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC. "
  265. (2001). Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. "
  266. (2003). Phosphorylation of eIF4E attenuates its interaction with mRNA 5 'cap analogs by electrostatic repulsion: Intein-mediated protein ligation strategy to obtain phosphorylated protein. "
  267. (2002). Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. "
  268. (1999). Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnkl in vivo. "
  269. (2004). PIAS i selectively inhibits interferon-inducible genes and is
  270. (1986). Point Mutations Define A Sequence Flanking The Aug Initiator Codon That Modulates Translation By Eukaryotic Ribosomes. "
  271. (2002). Polyamine depletion induces apoptosis through mitochondria- mediated pathway. "
  272. (1990). Polyamine Metabolism. "
  273. (2001). Polyamine regulation of ribosome pausing at the upstream open reading frame of S-adenosylmethionine decarboxylase. "
  274. (1981). Polyamines in mammalian tumors. Part I. "
  275. (1999). Posttranscriptional regulation of mammalian methionine synthase by B12. "
  276. (1993). Posttranscriptional Regulation Of The Heterochronic Gene Lin-14 By Lin-4 Mediates Temporal Pattern-Formation In C-Elegans. "
  277. (2004). Preferential translation of internal ribosome entry sitecontaining mRNAs during the mitotic cycle in mammalian cells. "
  278. (1997). Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. "
  279. (2002). Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha.
  280. (2002). Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HSI) in Jurkat cells. "
  281. (2001). Protein kinase CK2: Signaling and tumorigenesis in the mammary gland. " Molecular And Cellular Biochemistry
  282. (2003). Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. "
  283. (1999). Protein synthesis initiation factor 4G. "
  284. (1995). Protein-Kinase-C Isoforms In Rat-Kidney Proximal Tubule - Acute Effect Of Angiotensin-li. "
  285. (2004). Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients. "
  286. (1997). Rapamycin inhibits alpha 1-adrenergic receptorstimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase. "
  287. (1995). Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. "
  288. (1994). Rapamycin Selectively Inhibits Translation Of Messenger-Rnas Encoding Elongation-Factors And Ribosomal-Proteins. "
  289. (1994). Rapamycin Selectively Represses Translation Of The Polypyrimidine Tract Messenger-Rna Family. "
  290. (1997). Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70(S6k). "
  291. (1997). RB kinases and RB-binding proteins: New points of view. "
  292. (2002). Regulated translation termination at the upstream open reading frame in S-adenosylmethionine decarboxylase mRNA. "
  293. (1999). Regulation of 4E-BPI phosphorylation: a novel two-step mechanism. "
  294. (1996). Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukaemia. "
  295. (1998). Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2 alpha. "
  296. (2003). Regulation of JAK-STAT signalling in the immune system. "
  297. (2001). Regulation of STAT protein synthesis by cCbl. " Oncogene
  298. (1994). Regulation of translation and cell growth by eIF-4E. "
  299. (2000). Regulation of Weel kinase in response to protein synthesis inhibition. "
  300. (2001). Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. "
  301. (2002). Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. "
  302. (1977). Renin-angiotensin system: biochemistry and mechanisms of action. "
  303. (1995). Repression Of Cap-Dependent Translation By 4eBinding Protein-1 - Competition With P220 For Binding To Eukaryotic Initiation Factor4e. "
  304. (1996). Requirement of p27(Kip1) for restriction point control of the fibroblast cell cycle. "
  305. (1998). Resistance of CLL B cells to apoptosis: Involvement of type 1 (interferon-gamma) cytokine pathways. "
  306. (1992). Responsiveness Of Chronic LymphocyticLeukemia B-Cells Activated Via Surface Igs Or Cd40 To B-Cell Tropic Factors. "
  307. (2003). Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7. "
  308. (1999). Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. "
  309. (2002). Ribosome structure and the mechanism of translation. "
  310. (2003). Role of microRNAs in plant and animal development. "
  311. (1995). Role of p70 S6 protein kinase in angiotensin IIinduced protein synthesis in vascular smooth muscle cells. "
  312. (2003). Role of the microenvironment in chronic lymphocytic leukaemia. "
  313. (1999). Role of two upstream open reading frames in the translational control of oncogene mdm2. "
  314. (1989). Secondary Structure-Analysis Of Adenovirus Tripartite Leader. "
  315. (2001). Selection events operating at various stages in B cell development. " Current Opinion In
  316. (2004). Selective activation of protein kinase C isoforms by angiotensin II in neuroblastoma X glioma cells. "
  317. (1993). Selective Cleavage Of 28s Ribosomal-Rna Variable Regions
  318. (1996). Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells. "
  319. (1999). Selective usage of D-type cyclins in lymphoid malignancies. "
  320. (1997). Signal transduction pathways and mechanisms of apoptosis in CLL Blymphocytes: their role in CLL pathogenesis. "
  321. (2002). Siva-l binds to and inhibits BCL-X-L mediated protection against UV radiation induced apoptosis. "
  322. (1998). Somatic hypermutation in normal and transformed human B cells. "
  323. (1989). Spontaneous Programmed Death (Apoptosis) Of B-Chronic Lymphocytic-Leukemia Cells Following Their Culture Invitro. "
  324. (2003). STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1. "
  325. (2000). STATs in oncogenesis. " Oncogene
  326. (2002). Stats: transcriptional control and biological impact. "
  327. (1997). Stimulation of B-chronic lymphocytic leukemia cells by murine fibroblasts, IL-4, anti-CD40 antibodies, and the soluble CD40 ligand. "
  328. (1997). Structure of translation factor eIF4E bound to m(7)GDP and interaction with 4E-binding protein. "
  329. (1983). Studies On Transformation Of Escherichia-Coli With Plasmids. "
  330. (2002). Superoxide activates mitochondrial uncoupling proteins. "
  331. (1985). Surface-Markers In Chronic Lymphoid Leukemias Of B-Cell Type. " Seminars In
  332. (2001). Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. "
  333. (1995). Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. "
  334. (1995). Syk Tyrosine Kinase Required For Mouse Viability And B-Cell Development. "
  335. (2003). T-cell integrins: more than just sticking points. "
  336. (1998). Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity. "
  337. (2001). TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. "
  338. (2004). Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations. "
  339. (1998). Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia. "
  340. (2002). The 5' untranslated region of protein kinase Cdelta directs translation by an internal ribosome entry segment that is most active in densely growing cells and during apoptosis. "
  341. (2002). The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis. "
  342. (1996). The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. "
  343. (1990). The angiotensin II receptor and the actions of angiotensin II. "
  344. (1995). The Angiotensin-li Type-2 (At(2)) Receptor Antagonizes The Growth Effects Of The At(1) Receptor - Gain-Of-Function Study Using Gene-Transfer. "
  345. (2003). The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. "
  346. (1993). The C-Elegans Heterochronic Gene Lin-4 Encodes Small Rnas With Antisense Complementarity To Lin-14. "
  347. (2002). The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. "
  348. (1998). The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. "
  349. (2002). The caspase-cleaved DAPS protein supports internal ribosome entry site-mediated translation of death proteins. "
  350. (1988). The Catalytic Mechanism Of GuanineNucleotide Exchange Factor Action And Competitive-Inhibition By Phosphorylated Eukaryotic Initiation Factor-Ii. "
  351. (2004). The clinical and epidemiological burden of chronic lymphocytic leukaemia. "
  352. (1998). The DEAD box protein eIF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide. "
  353. (2001). The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II- mediated phosphorylation. "
  354. (2002). The direct recruitment of BLNK to immunoglobulin alpha couples the B-Cell antigen receptor to distal signaling pathways. "
  355. (2000). The double stranded RNA-activated protein kinase PKR. In
  356. (2000). The E2F transcription factors: key regulators of cell proliferation.
  357. (1999). The economics of ribosome biosynthesis in yeast. "
  358. (1998). The extended protein kinase C superfamily. "
  359. (1994). The Immunological Profile Of B-Cell Disorders And Proposal Of A Scoring System For The Diagnosis Of Cll. "
  360. (1998). The inhibitory upstream open reading frame from mammalian S- adenosylmethionine decarboxylase mRNA has a strict sequence specificity in critical positions. "
  361. (1993). The interaction of insulin and angiotensin II on the regulation of human neuroblastoma cell growth. "
  362. (2000). The joining of ribosomal subunits in eukaryotes requires eIF5B. "
  363. (1999). The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. "
  364. (1996). The mammalian immediate-early TIS21 protein and the leukemia- associated BTG1 protein interact with a protein-arginine Nmethyltransferase. "
  365. (2000). The many substrates and functions of ATM. "
  366. (1994). The Mdm2 Oncogene Overexpression In Chronic Lymphocytic- Leukemia And Low-Grade Lymphoma Of B-Cell Origin. "
  367. (1996). The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. "
  368. (2003). The mesenchymal stroma negatively regulates B cell lymphopoiesis through the expression of activin A. Hematopoietic Stem Cells 2002: Genetics And Function.
  369. (2004). The molecular mechanics of eukaryotic translation.
  370. (1995). The Novel Variants Of Mb-1 And B29 Transcripts Generated By Alternative Messenger-Rna Splicing. "
  371. (2003). The nuclear RNase III Drosha initiates microRNA processing. "
  372. (2000). The Pezcoller lecture: cancer cell cycles revisited. "
  373. (1998). The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. "
  374. (1997). The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. "
  375. (1995). The retinoblastoma protein and cell cycle control. "
  376. (2001). The ribosome in focus. "
  377. (2002). The role of activin A in regulation of hemopoiesis. "
  378. (1998). The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy. "
  379. (2002). The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. "
  380. (2003). The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. "
  381. (2003). The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. "
  382. (2004). The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells. "
  383. (1996). The upstream open reading frame of the mRNA encoding S- adenosylmethionine decarboxylase is a polyamine-responsive translational control element. "
  384. (2001). The WD motif-containing protein receptor for activated protein kinase C (RACKI) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. "
  385. (2003). The zipper model of translational control: A small upstream ORF is the switch that controls structural remodeling of an mRNA leader. "
  386. (2003). TM4: A free, open-source system for microarray data management and analysis. "
  387. (2002). Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. "
  388. (2000). Translation by ribosome shunting on adenovirus and hsp70 mRNAs facilitated by complementarity to 18S rRNA. "
  389. (1990). Translation By The Adenovirus Tripartite Leader - Elements Which Determine Independence From Cap-Binding Protein Complex. "
  390. (2000). Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells. "
  391. (1997). Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity. "
  392. (2003). Translation of the human angiotensin II type I receptor mRNA is mediated by a highly efficient internal ribosome entry site. " Mol Cell En do crin ol
  393. (2004). Translation-state analysis of gene expression in mouse brain after focal ischemia. "
  394. (1997). Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. "
  395. (1997). Translational regulation of yeast GCN4 -A window on factors that control initiator-tRNA binding to the ribosome. "
  396. (1990). Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo. "
  397. (1998). Trisomy 12 is seen within a specific subtype of B-cell chronic lymphoproliferative disease affecting the peripheral blood bone marrow and co-segregates with elevated expression of CDl Ia. "
  398. (2000). Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. "
  399. (2000). Tyrosine kinase SYK: essential functions for immunoreceptor signalling. "
  400. (1994). Tyrosine Kinases Lyn And Syk Regulate B-Cell Receptor-Coupled Ca2+ Mobilization Through Distinct Pathways. "
  401. (1995). Tyrosine Phosphorylation Of Shc Is Mediated Through Lyn And Syk In B-Cell Receptor Signaling. "
  402. (2001). Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. "
  403. (2003). Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. "
  404. (2003). Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. "
  405. (2003). Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. "
  406. (1999). Unmutated Ig V-H genes are associated with a more aggressive form of chronic lymphocytic leukemia. "
  407. (2000). Upstream open reading frames as regulators of mRNA translation. " Mol Cell Biol
  408. (1994). Use Of Monoclonal-Antibodies To Study The Structure And Function Of Eukaryotic Protein-Synthesis Initiation-Factor Eif- 2b. "
  409. (2003). Weel-dependent mechanisms required for coordination of cell growth and cell division. "
  410. (1998). Wheat germ poly(A) binding protein enhances the binding affinity of eukaryotic initiation factor 4F and (iso)4F for cap analogues. "
  411. (1992). Zap-70 -A 70 Kd Protein-Tyrosine Kinase That Associates With The Tcr Zeta-Chain. "
  412. (2004). ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. "
  413. (2004). ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. "
  414. (2003). ZAP-70 expression as a surrogate for immunoglobulin-variable- region mutations in chronic lymphocytic leukemia. "

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