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Exercise-induced Biochemical Modifications in Muscle in Chronic Kidney Disease: Occult Acidosis as a Potential Factor Limiting the Anabolic Effect of Exercise

By Emma L. Clapp and Alan Bevington


There is growing evidence that exercise may be beneficial in limiting or reversing problems related to chronic kidney disease (CKD); but exercise therapy has had limited success in increasing lean body mass, implying that metabolic abnormalities in muscle during CKD may limit the anabolic effectiveness of exercise. This short review summarizes evidence that exercise may result in a transient worsening of the pre-existing metabolic acidosis that occurs in these patients; a metabolic defect that may reverse the normal anabolic effects of exercise

Publisher: Elsevier on behalf of the Council on Renal Nutrition of the National Kidney Foundation and the International Society of Renal Nutrition and Metabolism
Year: 2011
DOI identifier: 10.1053/j.jrn.2010.10.023
OAI identifier:

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