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Detection of Chemical Weapon Agents and Simulants Using Chemical Ionization Reaction Time-of-Flight Mass Spectrometry

By Rebecca L. Cordell, Kerry A. Willis, Kevin P. Wyche, Robert S. Blake, Andrew M. Ellis and Paul S. Monks


This paper was published as Analytical Chemistry, 2007, 79 (21), pp. 8359-8366. Copyright © 2007 American Chemical Society. It is available from Doi: 10.1021/ac071193cMetadata only entryChemical ionization reaction time-of-flight mass spectrometry (CIR-TOF-MS) has been used for the analysis of prepared mixtures of chemical weapon agents (CWAs) sarin and sulfur mustard. Detection of the CWA simulants 2-chloroethyl ethyl sulfide, triethyl phosphate, and dimethyl methyl phosphonate has also been investigated. Chemical ionization of all the agents and simulants was shown to be possible using the CIR-TOF-MS technique with a variety of reagent ions, and the sensitivity was optimized by variation of instrument parameters. The ionization process was found to be largely unaffected by sample humidity levels, demonstrating the potential suitability of the method to a range of environmental conditions, including the analysis of CWAs in air and in the breath of exposed individuals

Publisher: American Chemical Society
Year: 2007
DOI identifier: 10.1021/ac071193c
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