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Glia as transmitter sources and sensors in health and disease

By António Miguel de Jesus Domingues, Mark Taylor and Robert Fern

Abstract

Glial cells express a bewildering array of neurotransmitter receptors. To illustrate the complexity of expression, we have assayed non-glutamatergic neurotransmitter receptor mRNA in isolated rat optic nerve, a preparation devoid of neurons and neuronal synapses and from which relatively pure “glial” RNA can be isolated. Of the 44 receptor subunits examined which span the GABA-A, nicotinic, adreno- and glycine receptor families, over three quarters were robustly expressed in this mixed population of white matter glial cells, with several expressed at higher levels than found in control whole brain RNA. In addition to the complexity of glial receptor expression, numerous neurotransmitter release mechanisms have been identified. We have focused on glutamate release from astrocytes, which can occur via at least seven distinct pathways and which is implicated in excitotoxic injury and are neurons and glia. Recent findings suggest that non-glutamatergic receptors can also mediate acute glial injury are also discussed.This work was supported by the National Institutes of Neurological Disorders and Stroke (NS44875 to RF).Post-prin

Topics: Glia, Glutamate, Neurotransmitter, Receptor
Publisher: Elsevier
Year: 2010
DOI identifier: 10.1016/j.neuint.2010.03.024
OAI identifier: oai:lra.le.ac.uk:2381/8038
Journal:

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Citations

  1. (1998). Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. doi
  2. (1996). Receptormediated calcium signalling in glial cells from mouse corpus callosum slices. doi

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