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Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats

By Todor V. Gerdjikov and Richard J. Beninger

Abstract

Background: The nucleus accumbens (NAc) plays a critical role in amphetamine-produced conditioned place preference (CPP). In previous studies, NAc basal and amphetamine-produced DA transmission was altered by Group II mGluR agents. We tested whether NAc amphetamine CPP depends on Group II mGluR transmission.\ud Results: NAc injections (0.5 μl/side) of the Group II mGluR antagonist (2 S)- a-ethylglutamic acid (EGLU: 0.01–0.8 μg but not 0.001 μg) impaired CPP. The drug did not block the acute locomotor effect of amphetamine.\ud Conclusion: Results suggest that Group II mGluRs may be necessary for the establishment of NAc amphetamine-produced CPP. These receptors may also mediate other forms of reward-related learning dependent on this structure

Publisher: BioMed Central
Year: 2006
DOI identifier: 10.1186/1471-2202-7-43
OAI identifier: oai:lra.le.ac.uk:2381/8008
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  1. (2003). A: Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaineinduced facilitation of brain reward function in rats. doi
  2. (2005). Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine. doi
  3. (2002). AE: Appetitive instrumental learing is impaired by inhibition of cAMPdependent protein kinase within the nucleus accumbens. Neurobiology of Learning and Memory doi
  4. (2002). AE: Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex.
  5. (2001). CRJ: Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE). Synapse doi
  6. (1998). DD: LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology doi
  7. (2005). Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. doi
  8. (2004). Gerdjikov T: The role of signaling molecules in reward-related incentive learning. Neurotox Res doi
  9. Gerdjikov TV: Dopamine-glutamate interactions in reward-related incentive learning. doi
  10. (2005). Grace AA: Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron doi
  11. (1997). Group 1 and 2 metabotropic glutamate receptors play differential roles in hippocampal long-term depression and long-term potentiation in freely moving rats. doi
  12. (2003). I: cAMP-dependent protein kinase and reward-related learning: intra-accumbens RpcAMPS blocks amphetamine-produced place conditioning in rats. Psychopharmacology (Berl) doi
  13. (1996). JC: Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology doi
  14. (2001). JR: A cellular mechanism of reward-related learning. doi
  15. (1999). Kalivas PW: The regulation of dopamine transmission by metabotropic glutamate receptors. J Pharmacol Exp Ther
  16. KC: The neural basis of drug craving: doi
  17. Laruelle M: Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography. Neuropsychopharmacology 2005, [Epub ahead of print]:. doi
  18. (1999). Levine MS: Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels. Brain Res doi
  19. (2001). Malenka RC: Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci doi
  20. (2004). Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron
  21. (2002). Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology doi
  22. (2003). Neural mechanisms of reward-related motor learning. Curr Opin Neurobiol
  23. (2003). Olive MF: The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse doi
  24. (2004). RE: Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) doi
  25. (1996). RJ: A computerized system for the simulatneous monitoring of place conditioning and locomotor activity in rats. doi
  26. (2005). RJ: Differential effects of calcineurin inhibition and protein kinase A activation on nucleus accumbens amphetamine-produced conditioned place preference in rats. doi
  27. (2004). RJ: Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in rats. Behav Neurosci doi
  28. (1998). S: CREB and memory. Annual Review of Neuroscience doi
  29. (1998). Schmidt WJ: Blockade of morphine- and amphetamine-induced conditioned place preference in the rat by riluzole. Neurosci Lett doi
  30. (2004). SN: Selective action of (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell. Neuropharmacology doi
  31. (2002). Sweatt JD: Molecular Psychology: Roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol doi
  32. (1998). The rat brain in stereotaxic coordinates. doi
  33. (1983). The role of dopamine in locomotor activity and learning. Brain Res Rev doi
  34. (2005). Trends Mol Med
  35. (1986). White NM: Anatomical disossiation of amphetamine's rewarding and aversive effects: an intracranial microinjection study. Psychopharmacology doi
  36. (1983). White NM: Conditioned place preference from intraaccumbens but not intra-caudate amphetamine injections. Life Sci doi
  37. (2005). YT: Nucleus accumbens long-term depression and the expression of behavioral sensitization. Science

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