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Nitric oxide, ischaemia and brain inflammation

By Sean P. Murphy and Claire L. Gibson

Abstract

Full text of this item is not currently available on the LRA. \ud The final published version is available at http://www.biochemsoctrans.org/bst/035/bst0351133.htm, Doi: 10.1042/BST0351133.Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors

Topics: brain, cerebral ischaemia, inducible nitric oxide synthase (iNOS), inflammation, nitric oxide, progesterone
Publisher: Portland Press
Year: 2007
DOI identifier: 10.1042/BST0351133
OAI identifier: oai:lra.le.ac.uk:2381/8004
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