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Hydrogenation in Supercritical 1,1,1,2-Tetrafluoroethane(HFC 134a).

By Andrew P. Abbott, Wayne Eltringham, Eric G. Hope and M. Nicola

Abstract

Conventional, unmodified, transition metal catalysts, substrates and reagents have sufficient solubility in sc HFC134a for organic synthesis. Reactivities (100% conversion in 2 h) and enantioselectivities (ca. 90%), comparable to those achievable in conventional organic solvents, are obtained in the asymmetric hydrogenation of a series of substrates in this alternative reaction medium using a rhodium(I)/MonoPhos catalyst.Peer-reviewedPublisher Versio

Publisher: The Royal Society of Chemistry
Year: 2005
DOI identifier: 10.1039/B507554H
OAI identifier: oai:lra.le.ac.uk:2381/604
Journal:

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