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Towards molecular systems biology of gene transcription and regulation

By Patrick Cramer


Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed

Topics: Chemie und Pharmazie, ddc:540
Publisher: 'Walter de Gruyter GmbH'
Year: 2010
DOI identifier: 10.1515/BC.2010.094
OAI identifier:
Provided by: Open Access LMU

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