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The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding.

By C.F. Damblon, M. Jensen, A. Ababou, Igor L. Barsukov, C. Papamicael, C.J. Schofield, L. Olsen, R. Bauer and Gordon C.K. Roberts
Year: 2003
DOI identifier: 10.1074/jbc.M301562200
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