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Studies on the Ecological Genetics of the Fieldmouse Apodemus Sylvaticus L.

By J. Andrew Leigh Brown


The results of many years work on the ecology of the fieldmouse (Apodenus sylveticus) present a sound background to a study of its ecological genetics. Gel electrophoresis and orbital bleeding techniques were used to pursue this.\ud A preliminary estimation of the degree of genetic variability in this species was made through studies on ten loci in 250 animals from eight populations. Similar levels of heterozygosity were observed to those found in the house mouse and two widespread polymorphisms were discovered at the lactate dehydrogenase regulator (Ldr) and phosphoglucomutase (PMG_2 ) loci. The eight populations were similar in gene frequencies at both.\ud To discover the degree of change which occurs in a population over a period of time, two sites were visited three times at six-monthly intervals. They showed great constancy in gene frequencies at both the PGM_2 and Ldr Ioci when large samples were available. A third site was sampled bimonthly for two years. No real change in gene frequency was observed at Ldr but at PGM_2 significant changes were found during one winter when numbers were high. As survival rates were low, these results suggest natural selection.\ud The most important single factor influencing survival in overwintering fieldmice is food supply. The central role that phosphoglucomutase plays in glycogen metabolism suggested that the enzyme itself might be subject to selection and experiments were designed to test this. Liver glycogen levels were measured in animals that had been starved overnight.\ud When analysed according to PGM_2 genotype a highly significant difference was found between the levels in aa animals and those in ac and cc genotypes. This pattern was the same as that found in the survival rates of a large overwintering natural population. It was concluded that these genotypes are not neutral with respect to selection

Publisher: University of Leicester
Year: 1976
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  38. Genetic changes in a population of fieldmice (Anodemus sylvaticus) during one doi
  39. (1975). Genetic differentiation during the spediation process.
  40. (1972). Genetic distance between populations. doi
  41. (1970). Genetic heterogeneity within electrophoretic "alleles'' of xanthine dehydrogenase in Drosophila pseudoobscura. Genetics.
  42. (1971). Genetic polymorphisms in variedý environments. doi
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  52. (1967). Hormonal control of phosphoglucomutase activity. doi
  53. (1963). Human red epil phosphogluconate dehydrogenases. doi
  54. (1962). Incorporation of 14C-glucose into glycogen by whole homogenate of liver. doi
  55. (1972). Inherited partial deficiency of the PGM i gene : biochemical anddensitometric studies.
  56. (1968). Lactate dehydrogenase genes in rodents. doi
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  60. (1970). Molecular size estimates of the hu-man phosphoglucomutase isozymes by gel filtration chromatography. doi
  61. (1966). Monthly frequency changes of Drosophila pseudoobscura third chromosome gene arrangements in a California Locality. Evolution. Lancaster Pa. doi
  62. Mortality among voles (Microtus agrestis) at Lake Vyrnwyt Montgomeryshire in 1936-9. doi
  63. (1964). Movement, activity and distribution of the small rodents Clethrionomya glareolus and I Apodemul sylvatIcu in woodland.
  64. (1967). Multiple forms of phosphoglucomutase. doi
  65. (1969). Non-Darwinian evolution : random fixation of selectively neutral mutations.
  66. (1969). Phosphoglucomutase electrophoretic variants in the mouse. doi
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  68. (1971). Polymorphism and protein evolution. The neutral' . -, utation - random drift hyliothesis. doi
  69. (1969). Polymorphism in esterases and hemoglobin in wild populations of the house mouse (Lus Rus.
  70. (1973). Polymorphism in random environments. doi
  71. (1971). Polyr-orphisms in continental and island,
  72. (1973). Population cycIcs in small rodents.
  73. (1969). Presence of two or more glucose 6-phosphate pools in voluntary skeletal muscle and their sensitivity to insulin. Endocrinology. doi
  74. (1965). Problems of live trapping and population estimation for the wood mouse Apodemus sylvaticus L. doi
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  76. Protein evolution and the molecular clock. doi
  77. (1969). Protein polymorphism and genic heterozygosity in a wild population of the house mouse (LIus musculus). doi
  78. (1967). Purification and propert'j6es of t'glucose i-phosphate kinasell, Life Science. n. 6: i gi -196.
  79. (1970). Recent advances in insect population dynamics. doi
  80. (1975). Red cell metabolism 2nd Edn.
  81. (1964). Regulation of glucose uptake by muscle. doi
  82. (1950). Selection in, the polymorphic land snail fe. Eaea nemoralis. doi
  83. (1966). Serum esteracea of Apodf?.. -nus sylvatious and Mus misculus.
  84. (1963). Skeletal muscle glycogenosis : an investigation of two dissimilar cases. doi
  85. Starch gel electrophoresis in a discontinuous system of buffers. doi
  86. (1967). Statistical methods. 6th Edn. doi
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  88. (1942). Studies of a small mammal poýpulation in Bagley IvVood,
  89. (1967). Studies of natural populations of Mus. III. Coat colour polymorphisms. doi
  90. (1968). Studies on phosphomutases. II. Effects of i. 3-diphosphoglycerate on phosphoglucomutase,
  91. (1960). Super-genes and mimicry. doi
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  97. (1966). The ecology of woodland voles and mice with special reference to movement and population structure. Unpublished
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  102. (1968). The foods eaten by wood mice and bank voles in Vytham Woods. doi
  103. (1964). The Handbook of British Mammals. doi
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  105. (1964). The lem-ning cycle at Baker Lake, Northwest Territories, during 1959-62.
  106. (1966). The pattern of animalcommunities. Methuen London.
  107. (1968). The pattern of distribution of prey and preclation in tawny owl territories. doi
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  110. (1946). The source of animals moving into a depopulated nrea. doi
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  112. (1970). Thermostability studies on the isozymes of human phosphoglucomutase. doi
  113. (1954). Tuberculosis among wild vole3 : with a discussion of other pathological conditions among g 227 certain mammals and birds. doi
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