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Studies on the Ecological Genetics of the Fieldmouse Apodemus Sylvaticus L.

By J. Andrew Leigh Brown

Abstract

The results of many years work on the ecology of the fieldmouse (Apodenus sylveticus) present a sound background to a study of its ecological genetics. Gel electrophoresis and orbital bleeding techniques were used to pursue this.\ud A preliminary estimation of the degree of genetic variability in this species was made through studies on ten loci in 250 animals from eight populations. Similar levels of heterozygosity were observed to those found in the house mouse and two widespread polymorphisms were discovered at the lactate dehydrogenase regulator (Ldr) and phosphoglucomutase (PMG_2 ) loci. The eight populations were similar in gene frequencies at both.\ud To discover the degree of change which occurs in a population over a period of time, two sites were visited three times at six-monthly intervals. They showed great constancy in gene frequencies at both the PGM_2 and Ldr Ioci when large samples were available. A third site was sampled bimonthly for two years. No real change in gene frequency was observed at Ldr but at PGM_2 significant changes were found during one winter when numbers were high. As survival rates were low, these results suggest natural selection.\ud The most important single factor influencing survival in overwintering fieldmice is food supply. The central role that phosphoglucomutase plays in glycogen metabolism suggested that the enzyme itself might be subject to selection and experiments were designed to test this. Liver glycogen levels were measured in animals that had been starved overnight.\ud When analysed according to PGM_2 genotype a highly significant difference was found between the levels in aa animals and those in ac and cc genotypes. This pattern was the same as that found in the survival rates of a large overwintering natural population. It was concluded that these genotypes are not neutral with respect to selection

Publisher: University of Leicester
Year: 1976
OAI identifier: oai:lra.le.ac.uk:2381/4733

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  1. (1974). 2' and PGM 3) in human tissues. doi
  2. (1968). A biochemical and ecological study of plasma esterase polarmorphism in natural populations of the field vole Micro-tus Rzrr-etis- doi
  3. (1975). A deterministic model of cyclical selection. doi
  4. (1974). A general model to account for enzyme variation in natural populations. doi
  5. (1974). A kinetic Gtudy of the isozymes determined by the three human phosphcglucomutase loci,
  6. (1966). A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different-loci in Drosophila pseudoobscura.
  7. (1972). A molecular approach to the study of genic'heterozygositY in natural populations. IV. Patterns of genic variation in centralp marginal and isolated populations of Drosophila pseudoobscura.
  8. (1966). Activation of phosphoglucomutase. doi
  9. (1960). Adaptation of orbital bleeding technique to rapid serial blood studies. doi
  10. (1973). Ageing in an island population of the house mouse. doi
  11. (1969). An analysis of gene-enzyme variability in natural populations of DrosophilR melanogaster and D. doi
  12. (1974). An analysis of selection at two loci in fluctuating populations of Microtus. doi
  13. BAchemical genetics of sibling species of the* cotton rat (Sigmodon).
  14. (1970). Behaviour and genetic variation in natural populations. doi
  15. (1957). Chemical procedures for analysis of polysacqharides. doi
  16. (1975). Complementarity in the regulation of pho,, -, phcglucc,, -,. '. I, taý->et -he role of glucose phosphofructok. inase and hexokinase; I.,
  17. (1966). Demographic changes in fluctuating populations of Microtus callfornicus. doi
  18. (1975). Demographic consequences of artificial selection at the LAP locus in voles (Microtus townsendii). doi
  19. (1970). Ecological structure and gene flo-w in small mammals. doi
  20. (1973). ecology of small mammals in fields drilled with winter wheat and the increase in their dieldrin and mercury residues. doi
  21. (1967). Effect of glucagon and epinephrine on cyclic MT. levels in rat liver.
  22. (1966). Ein neuer phanotyp im isoenzymsystem der phosphoglukomutasen des raenschen doi
  23. (1967). election of* colf-re-i-latory D.
  24. (1975). Enzyme jolymorphism
  25. (1972). Enzyme variability in the Drosophila willistoni group. V. Genic variation in natural populations of DrosoT)hila couinoxialis.
  26. (1968). Enzymic processes in glycogen metabolism. In. Carbohydrate Metabolism and its
  27. (1969). Esterase heterogeneity ; dynamics of a-polymorphism. doi
  28. (1965). Estimation of glycogen in small amounts of tissue. doi
  29. (1971). Evolutionary oscillations in Drosophila doi
  30. (1968). Evolutionary rate at tho molecular level.
  31. (1968). Experiments on population control by territorial behaviour in red grouse. doi
  32. (1974). Field and laboratory experiments on the social-behaviour and population dynamics of -the wood mouse (Apodemus sylvaticusl). doi
  33. (1968). Field experiments on the movements of Apodemus sylvaticus L. using tracking and backing techniques. doi
  34. (1968). Function of the lactate dehydrogenase B gene in mouse erythrocytes evidence for control by'a regulatory gene. doi
  35. (1971). Further studies on the mimetic butterfly Papilip memnon doi
  36. (1972). Galactose metabolism of mammalian erythrocytes. doi
  37. (1974). Genetic and social structure of feral house mouse populations on Grizzly Island, doi
  38. Genetic changes in a population of fieldmice (Anodemus sylvaticus) during one doi
  39. (1975). Genetic differentiation during the spediation process.
  40. (1972). Genetic distance between populations. doi
  41. (1970). Genetic heterogeneity within electrophoretic "alleles'' of xanthine dehydrogenase in Drosophila pseudoobscura. Genetics.
  42. (1971). Genetic polymorphisms in variedý environments. doi
  43. (1974). Genic differentiation within and bet,. -; een species of the DrosoRhila willistoni group.
  44. (1970). Genic variation in hybridising populations of gophers (Genus Thomomys). doi
  45. (1970). Glucagoil 'Levels and metabolic effects in fasting man. doi
  46. (1974). Glucose metabolism. In. The liver : normal and abnormal functions. Part
  47. (1961). Glycogen in erythrocytes of, patients with glycogen storage disease,
  48. (1974). Glycogen repletion in different types of nuse"Le and in liver after exhausting exercise.
  49. (1968). Glycogen-storage diseases : Types I, IIIp IV9 V, VII and unclassified glycogenoses. doi
  50. (1968). Historical studies and woodland conservation. In. The Scientific management of animal and plant communities for conservation.
  51. (1968). Hormonal control of carbohydrate metabolism in muscle.
  52. (1967). Hormonal control of phosphoglucomutase activity. doi
  53. (1963). Human red epil phosphogluconate dehydrogenases. doi
  54. (1962). Incorporation of 14C-glucose into glycogen by whole homogenate of liver. doi
  55. (1972). Inherited partial deficiency of the PGM i gene : biochemical anddensitometric studies.
  56. (1968). Lactate dehydrogenase genes in rodents. doi
  57. (1976). Microtus population biology : dispersal in fluctuating populations of M-townsendii. doi
  58. (1969). Microtus population biology II. Genetic changes at the transferrin. locus in fluctuating populations. doi
  59. (1969). Microtus population biology. I. Demographic changes in fluctuating populations of M. ochrogaster and Lt. pennsylvanicus in southern Indiana. doi
  60. (1970). Molecular size estimates of the hu-man phosphoglucomutase isozymes by gel filtration chromatography. doi
  61. (1966). Monthly frequency changes of Drosophila pseudoobscura third chromosome gene arrangements in a California Locality. Evolution. Lancaster Pa. doi
  62. Mortality among voles (Microtus agrestis) at Lake Vyrnwyt Montgomeryshire in 1936-9. doi
  63. (1964). Movement, activity and distribution of the small rodents Clethrionomya glareolus and I Apodemul sylvatIcu in woodland.
  64. (1967). Multiple forms of phosphoglucomutase. doi
  65. (1969). Non-Darwinian evolution : random fixation of selectively neutral mutations.
  66. (1969). Phosphoglucomutase electrophoretic variants in the mouse. doi
  67. (1964). Phosphoglucomutase polymorphism in man. doi
  68. (1971). Polymorphism and protein evolution. The neutral' . -, utation - random drift hyliothesis. doi
  69. (1969). Polymorphism in esterases and hemoglobin in wild populations of the house mouse (Lus Rus.
  70. (1973). Polymorphism in random environments. doi
  71. (1971). Polyr-orphisms in continental and island,
  72. (1973). Population cycIcs in small rodents.
  73. (1969). Presence of two or more glucose 6-phosphate pools in voluntary skeletal muscle and their sensitivity to insulin. Endocrinology. doi
  74. (1965). Problems of live trapping and population estimation for the wood mouse Apodemus sylvaticus L. doi
  75. (1976). Progress in the neutral mutationrandom drift controversy.
  76. Protein evolution and the molecular clock. doi
  77. (1969). Protein polymorphism and genic heterozygosity in a wild population of the house mouse (LIus musculus). doi
  78. (1967). Purification and propert'j6es of t'glucose i-phosphate kinasell, Life Science. n. 6: i gi -196.
  79. (1970). Recent advances in insect population dynamics. doi
  80. (1975). Red cell metabolism 2nd Edn.
  81. (1964). Regulation of glucose uptake by muscle. doi
  82. (1950). Selection in, the polymorphic land snail fe. Eaea nemoralis. doi
  83. (1966). Serum esteracea of Apodf?.. -nus sylvatious and Mus misculus.
  84. (1963). Skeletal muscle glycogenosis : an investigation of two dissimilar cases. doi
  85. Starch gel electrophoresis in a discontinuous system of buffers. doi
  86. (1967). Statistical methods. 6th Edn. doi
  87. (1973). Strategiep of biochemical adaptation. doi
  88. (1942). Studies of a small mammal poýpulation in Bagley IvVood,
  89. (1967). Studies of natural populations of Mus. III. Coat colour polymorphisms. doi
  90. (1968). Studies on phosphomutases. II. Effects of i. 3-diphosphoglycerate on phosphoglucomutase,
  91. (1960). Super-genes and mimicry. doi
  92. (1966). Sympatric speciation. doi
  93. Synthesis of cardiac glycogen in relation to ite 21ý hour r1aythm in rats.
  94. th 111ollanA Harris, If.
  95. (1966). The concept of home range in mammals.
  96. (1975). The contribution of ecological gcn--tic3 to evolutionary theory : detecting the direct effects of natural selection on particular polymorphic loci..
  97. (1966). The ecology of woodland voles and mice with special reference to movement and population structure. Unpublished
  98. The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycaemia in man. doi
  99. (1972). The effect of supplementary food on a population of-wood mice (Apodemus sylvaticus). doi
  100. (1969). The estimation and biology of populations of the bank vole (Clethrionomyq glaredus (Schr. )) and the wood mouse (Apodemus sylvaticus doi
  101. (1973). The evolution-of melanism. doi
  102. (1968). The foods eaten by wood mice and bank voles in Vytham Woods. doi
  103. (1964). The Handbook of British Mammals. doi
  104. (1971). The influence of adrenergic receptor stimulation on glucose metabolism during starvation in man : Effects on circulating levels of insulin, growth hormone and free fatty acids. doi
  105. (1964). The lem-ning cycle at Baker Lake, Northwest Territories, during 1959-62.
  106. (1966). The pattern of animalcommunities. Methuen London.
  107. (1968). The pattern of distribution of prey and preclation in tawny owl territories. doi
  108. (1975). The principles of human biochemical " --d
  109. (1969). The regulation of wood mouse (Apodemus sylvatiCUS) numbers in doi
  110. (1946). The source of animals moving into a depopulated nrea. doi
  111. (1971). Theoretical aspects of population genetics.
  112. (1970). Thermostability studies on the isozymes of human phosphoglucomutase. doi
  113. (1954). Tuberculosis among wild vole3 : with a discussion of other pathological conditions among g 227 certain mammals and birds. doi
  114. (1972). Two coat colour variants in the prairie vole.
  115. (1964). Use of liver. adenyl cyclase for assay of glucagon in human gastro-intestinal tract and pancreas. doi

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