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Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis

By Robert A. Hirst, Bejal Gosai, Andrew Rutman, Peter W. Andrew and Christopher L. O'Callaghan

Abstract

Copyright © 2003, American Society for Microbiology. Also available from the publisher website at http://iai.asm.org/.Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that has been neglected in the study of meningitis is the ependyma, which has been identified as a\ud location of adult pluripotent cells. In this study we have used a rat model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae. The effects included localized loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the ependymal ultrastructure during meningitis. In\ud conclusion, loss of ependymal cells and ciliary function exposes the underlying neuronal milieu to host and bacterial cytotoxins and this is likely to contribute to the neuropathology commonly observed in pneumococcal meningitis

Publisher: American Society for Microbiology
Year: 2003
OAI identifier: oai:lra.le.ac.uk:2381/2683

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Citations

  1. (1995). A new approach for multiple sampling of cisternal cerebrospinal fluid in rodents with minimal trauma and inflammation 157. doi
  2. (2000). Acute bacterial meningitis in adults. A 12-year review. Medicine doi
  3. (2000). Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells. doi
  4. (1995). Ependymal reactions to injury. A review. doi
  5. (1985). Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment 79. doi
  6. (2000). Host cellular immune response to pneumococcal lung infection in mice. doi
  7. (1999). Identification of a neural stem cell in the adult mammalian central nervous system. doi
  8. (1999). Models of experimental bacterial meningitis. Role and limitations. doi
  9. (1999). Pathogenesis of bacterial meningitis. doi
  10. (2002). Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis 37. doi
  11. (2002). Prevention of pneumococcal meningitis. doi
  12. (2003). Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency. doi
  13. (1990). Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis. Acta Neurochir. Suppl. doi
  14. (1999). The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia. doi
  15. (1995). The ependyma: a protective barrier between brain and cerebrospinal fluid. doi
  16. (2000). The subventricular zone: source of neuronal precursors for brain repair 26. Prog. Brain Res. doi
  17. (1997). Treatment of bacterial meningitis. doi

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