Skip to main content
Article thumbnail
Location of Repository

Fast spin-echo and fast fluid-attenuated inversion-recovery versus conventional spin-echo sequences for MR quantification of multiple sclerosis lesions

By S. Bastianello, A. Bozzao, A. Paolillo, E. Giugni, C. Gasperini, T. Koudriavtseva, E. Millefiorini, Mark A. Horsfield, C. Colonnese, D. Toni, M. Fiorelli, C. Pozzilli and L. Bozzao


This article was published in American Journal of Neuroradiology and is available through their website at To compare fast spin-echo (FSE) and fast fluid-attenuated inversion recovery (FLAIR) sequences with conventional spin-echo (CSE) MR imaging in the quantification of the number and volume of multiple sclerosis lesions. METHODS: In 30 patients with relapsing-remitting multiple sclerosis, we calculated the total number and volume of lesions detected with each of the three sequences using a semiautomated program. RESULTS: On CSE sequences, we calculated a total of 2,583 lesions with a global volume of 836.3 cm3. With FSE sequences, we observed a 16% relative reduction in the number of lesions detected and a 25% relative reduction in global volume as compared with CSE. With fast FLAIR sequences, we detected a significantly lower number and volume of infratentorial lesions, whereas at the cortical/subcortical level the lesions were both more numerous and bulkier than on CSE sequences. Finally, we observed a higher lesion/white matter contrast, a significant reduction in time required for the quantification of lesion load, and a very low interobserver variability in favor of fast FLAIR sequences. CONCLUSION: Despite its limitations in the detection of infratentorial lesions, the fast FLAIR sequence in conjunction with a semiautomated quantification program provides a reliable means to evaluate the total lesion burden in patients with MS

Publisher: American Society of Neuroradiology.
Year: 1997
OAI identifier:

Suggested articles


  1. (1993). Accuracy and reproducibility in volumetric analysis of multiple sclerosis lesions. doi
  2. (1993). Anatomical and functional correlates of cognitive deficit in multiple sclerosis. doi
  3. (1995). Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. doi
  4. Cortical plaques visualized by fluid-attenuated inversion recovery imaging in multiple sclerosis. doi
  5. (1992). Depression in the early phase of MS: influence of functional disability, cognitive impairment and brain abnormalities. doi
  6. (1995). Fluid attenuated inversion recovery (FLAIR) sequences in multiple sclerosis: contrast parameters in a steady state and comparison with spin-echo sequences. Magn Reson Imaging doi
  7. (1995). Intra- and inter-observer agreement of brain MRI lesion volume measurements in multiple sclerosis: a comparison of techniques. Brain doi
  8. (1996). Involvement of the limbic system in multiple sclerosis patients with depressive disorders. doi
  9. (1994). Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. doi
  10. (1992). MR of the brain using fluid-attenuated inversion recovery (FLAIR) pulse sequence. doi
  11. MRI of the brain stem using fluid-attenuated inversion recovery (FLAIR) sequence. doi
  12. Quantitative assessment of MRI lesion load in multiple sclerosis: a comparison of conventional spin-echo with fast-fluid attenuated inversion recovery.Brain 1996;2:1349–1355 doi
  13. Quantitative MRI studies for assessment of MS. doi
  14. (1997). Rating neurologic impairment in multiple sclerosis: an 704 doi
  15. (1995). Suspected multiple sclerosis: MR imaging with a thin-section fast FLAIR pulse sequences. Radiology doi
  16. (1992). Use of fluid attenuated inversion recovery (FLAIR) pulse sequence in MRI of the brain. doi
  17. (1992). Volume measurements of multiple sclerosis lesions with magnetic resonance images: a preliminary study. doi
  18. (1992). Volume measurements of multiple sclerosis with magnetic resonance images: a preliminary study. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.