Location of Repository

Interhemispheric Asymmetry of Brain Diffusivity in Normal Individuals: A Diffusion-Weighted MR Imaging Study.

By A. J. Fabiano, Mark A. Horsfield and Rohit Bakshi

Abstract

This is the version as published byAmerican Society of Neuroradiology. It is available online at\ud http://www.ajnr.org/cgi/reprint/26/5/1089BACKGROUND AND PURPOSE: Previous neuroimaging studies have suggested asymmetries in brain diffusivity may exist. The purpose of this study was to assess whether water diffusivity in deep gray matter structures shown by diffusion-weighted (DW) imaging differs between the right and left cerebral hemispheres in normal individuals. \ud \ud METHODS: Brain MR imaging was obtained in 23 healthy volunteers. A multisection image without diffusion weighting, and images with weighting applied in the read, phase, and section directions with a b-factor of 1000 s/mm2 were collected. Diffusivity was computed separately in each direction, and the results were averaged to form mean diffusivity maps. Quantitative diffusivity values were obtained from the globus pallidus, putamen, caudate, thalamus, white matter, and CSF by using a standardized region of interest template. Interhemispheric differences were assessed by using a paired sample t test. \ud \ud RESULTS: Mean diffusivity was higher in the: left (mean ± SD: 0.689 x 10–3± 0.069 x 10–3mm2/s) versus right (0.642 x 10–3± 0.071 x 10–3mm2/s) caudate (% difference, P value: 7.0%, P = .001); right (0.745 x 10–3± 0.053 x 10–3mm2/s) versus left (0.706 x 10–3± 0.050 x 10–3mm2/s) globus pallidus (5.2%, P < .001); left (0.720 x 10–3± 0.059 x 10–3mm2/s) versus right (0.674 x 10–3± 0.052 x 10–3mm2/s) putamen (6.4%, P < .001); right (0.750 x 10–3± 0.040 x 10–3mm2/s) versus left (0.716 x 10–3± 0.031 x 10–3mm2/s) thalamus (4.5%, P < .001). No significant right versus left difference was seen in the CSF (P = .291), anterior frontal white matter (P = .834), or centrum semiovale (P = .320). \ud \ud CONCLUSION: Gray matter diffusivity may differ between hemispheres of the brain in healthy individuals. Analysis of deep gray matter lesions requires caution, as statistically significant interhemispheric differences may not always be indicative of disease

Publisher: American Society of Neuroradiology
Year: 2005
OAI identifier: oai:lra.le.ac.uk:2381/483

Suggested articles

Preview

Citations

  1. Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis. doi
  2. Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between doses, environment, and neuronal phenotype. doi
  3. An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. doi
  4. Brain morphometry in autistic men as measured by volumetric computed tomography. doi
  5. (1998). Calculation of apparent diffusion coefficients (ADCs) in brain using two-point and six-point methods. doi
  6. Changes on diffusionweighted MRI with focal motor status epilepticus: case report.
  7. Comparison of regional white matter diffusion in healthy neonates and adults performed with a doi
  8. Detection of acute thalamo-mesencephalic infarction: diffusion abnormality precedes T2 hyperintensity. doi
  9. Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: a pilot study.
  10. Diffusion-weighted imaging of cerebritis.
  11. Diffusion-weighted imaging provides support for secondary neuronal damage from intraparenchymal hematoma. doi
  12. Diffusion-weighted MR imaging in normal human brains in various age groups.
  13. Echo-planar and gradient-echo diffusion MRI of normal brain iron in the globus pallidus. doi
  14. Effect of hydrophilic components of the extracellular matrix on quantifiable diffusionweighted imaging of human gliomas: preliminary results of correlating apparent diffusion coefficient values and hyaluronan expression levels. doi
  15. Effects of GABA-uptake inhibitor tiagabine in rat globus pallidus. doi
  16. Human brain hemorrhage: quantification of perihematoma edema by use of diffusionweighted MR imaging.
  17. Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations. doi
  18. (2003). MR imaging of the brain in patients with hepatic form of Wilson’s disease. doi
  19. (1999). Optimal strategies for measurement of anisotropic diffusion. doi
  20. (1997). Optimized diffusionweighting for measurements of apparent diffusion coefficient (ADC) in human brains. Magn Reson Imaging
  21. (1998). Partial volume decrease of the thalamus in relatives of patients with schizophrenia. doi
  22. (1996). PET and MRI of the thalamus in never-medicated patients with schizophrenia. doi
  23. Quantitative diffusion-weighted MR imaging in transient ischemic attacks.
  24. Reduced thalamic volume in high-functioning individuals with autism. doi
  25. Regional ADC values of the normal brain: differences due to age, gender, and laterality.
  26. Sensitivity and interrater agreement of CT and diffusion-weighted MR imaging in hyperacute stroke.
  27. Stereotactic localization, intersubject variability, and interhemispheric differences of the human auditory thalamocortical system. doi
  28. Temporal relationship between apparent diffusion coefficient and absolute measurements of cerebral blood flow in acute stroke patients. doi
  29. (1999). The thalamus and the schizophrenia phenotype: failure to replicate reduced volume. Biol Psychiatry doi
  30. (1998). Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biol Psychiatry doi
  31. Weekly diffusionweighted imaging of normal appearing white matter in MS. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.