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Probing elastic modulus and depth of bottom-supported inclusions in model tissues using piezoelectric cantilevers

By Hakki Yegingil, Wan Y. Shih and Wei-Heng Shih

Abstract

Review of Scientific Instruments,78(11): pp. 115101-1-6.We have experimentally investigated the depth sensitivity limit of a piezoelectric cantilever tissue elastic modulus sensor and simultaneously determined the elastic modulus and the depth of a tumor directly. Using model tissues consisting of bottom-supported modeling clay inclusions of various depths in a gelatin matrix, we empirically determined that the depth sensitivity limit of a piezoelectric cantilever sensor was twice the linear dimension of the indentation area or the cantilever width . Knowing the depth sensitivity limit of the individual cantilever sensor as input and treating a model tissue that has the gelatin matrix on top and the modeling clay inclusion at the bottom as two springs in series, we showed that the elastic moduli and depths of the hard inclusions could be simultaneously determined with the elastic modulus profiles measured by two cantilevers with different widths as input

Publisher: 'AIP Publishing'
Year: 2008
DOI identifier: 10.1063/1.2793502
OAI identifier: oai:idea.library.drexel.edu:idea_2684

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