Article thumbnail

The relation between insulin-like growth factor I levels and cognition in healthy elderly: a meta-analysis

By L I Arwert, J B Deijen and M L Drent


OBJECTIVE: Insulin-like growth factor I (IGF-I) levels and cognitive functioning decrease with aging. Several studies report positive correlations between IGF-I levels and cognitive functioning in healthy elderly. However, because of controversial data no definitive conclusions can be drawn concerning the relation between IGF-I and cognition. Therefore, we carried out a meta-analysis on studies that report on the relation between IGF-I and cognition in healthy elderly. DESIGN: We searched the electronic databases for articles about IGF-I and cognition. Studies from 1985 to January 2005 are included. Two reviewers independently extracted data on study design and cognitive outcomes. Thirteen studies on IGF-I and cognition in elderly, with a total number of 1981 subjects, met the inclusion criteria. On the data from these studies meta-analyses were carried out by means of the program Comprehensive Meta-analysis using a random effects model. RESULTS: Pooled effects show that IGF-I levels in healthy elderly have a positive correlation with cognitive functioning, which appeared to be mainly measured with the mini mental state examination (MMSE). The effect size is 0.6, which indicates the presence of a large positive relationship between IGF and cognition in healthy elderly. CONCLUSION: These meta-analyses showed an overall relationship between IGF-I levels and cognitive functioning in healthy elderly. Further studies should be performed to clarify the role of IGF-I substitution in preserving cognitive functions with aging

Topics: Aged, Aged, 80 and over, Aging, Attention, Cognition, Cognition Disorders, Female, Growth Hormone, Humans, Insulin-Like Growth Factor Binding Protein 3/blood, Insulin-Like Growth Factor Binding Proteins/metabolism, Insulin-Like Growth Factor I/biosynthesis, Male, Memory, Memory Disorders, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Surveys and Questionnaires
Year: 2005
DOI identifier: 10.1016/j.ghir.2005.09.001
OAI identifier:
Provided by: NARCIS
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.