Article thumbnail

Maltodextrins as drying auxiliary agent for the preparation of easily resuspendable nanoparticles

By G. Magri, S. Franz&#233, U.M. Musazzi, F. Selmin and F. Cilurzo

Abstract

The drying of biodegradable polymeric nanoparticles (NP) is mandatory to improve their physical and chemical stability over time. Spray- or freeze-drying can induce irreversible aggregation of NP and therefore the use of drying auxiliary agents is required. The ability of four grades of maltodextrins differing in dextrose equivalent (DE) (i.e. DE2, DE6, DE12 and DE38) to protect PLGA NP from stresses was studied. High Mw maltodextrins (DE2) was not functional for obtaining an easily resuspendable dried product, since it needs a prolonged time to fully hydrate. Maltodextrins at intermediate DE showed a poor ability to protect NP from irreversible aggregation probably because too sensitive to environmental variation. DE38, which did not alter \u3b6-potential of NP, allowed to obtain an easily resuspendable nanosuspension independently of the drying process. The effectiveness of such material was attributed to the easiness of spray-dry a low viscous solution and to the ability of substitute the water molecules\u2019 hydrogen bonds with NP during freeze-drying

Topics: Freeze-dryingMaltodextrinsNanoparticlesResuspendabilitySpray-drying, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Publisher: 'Elsevier BV'
Year: 2019
DOI identifier: 10.1016/j.jddst.2019.01.019
OAI identifier: oai:air.unimi.it:2434/614773

Suggested articles


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.