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Cytokine profiles in drug-naive schizophrenic patients

By C.L. Cazzullo, E. Sacchetti, A. Galluzzo, A. Panariello, F. Colombo, A. Zagliani and M. Clerici


A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-gamma] in drug-free (n=26) and drug-naive (n=7) schizophrenic patients and in healthy controls (n=33). Production of IL-2 and INF-gamma was significantly higher (respectively P=0.021 and P=0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patient

Topics: Settore MED/04 - Patologia Generale
Publisher: 'Elsevier BV'
Year: 2001
DOI identifier: 10.1016/S0920-9964(00)00046-3
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