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Purinergic control of neutrophil activation

By F.M. Grassi


Neutrophils constitute the first line of defense against invading pathogens, but they also are responsible for tissue destruction in pathological conditions. In a recent paper published in Science Signaling, Junger and colleagues show that adenosine 5'-triphosphate release and signaling through purinergic P2 receptors upon neutrophil activation by bacterial and inflammatory stimuli represents an important mechanism for effective neutrophil functional response and host protection

Topics: Settore BIO/13 - Biologia Applicata
Publisher: 'Oxford University Press (OUP)'
Year: 2010
DOI identifier: 10.1093/jmcb/mjq014
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