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Structural and Conformational Studies of 3-(6-Chloropyridazin-3-yl)-N,N-dimethylpiperazinium Iodide and 3-(6-Chloropyridazin-3-yl)-N,N-dimethylhomopiperazinium Iodide with Central Nicotinic Action

By R. Artali, G. Bombieri and F. Meneghetti


The structural characteristics of 3-(6-chloropyridazin-3-yl)-N,N-dimethylpiperazinium iodide (3c) and 3-(6-chloropyridazin-3-yl)-N,N-dimethylhomopiperazinium iodide (4c) have been investigated in order to understand their actions at the nAchR receptor. The results of the X-Ray molecular structures and of the conformational analysis have been compared with the structure of epibatidine that represents one of the most potent nicotinic agonist

Topics: Settore CHIM/08 - Chimica Farmaceutica
Publisher: 'Japan Institute of Heterocyclic Chemistry'
Year: 2003
DOI identifier: 10.3987/COM-03-9826
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